Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer
Abstract Background Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, the prognostic values of inflammato...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-020-01566-8 |
| _version_ | 1828921172171948032 |
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| author | Minoru Oshima Keiichi Okano Hironobu Suto Yasuhisa Ando Hideki Kamada Tsutomu Masaki Shigeo Takahashi Toru Shibata Yasuyuki Suzuki |
| author_facet | Minoru Oshima Keiichi Okano Hironobu Suto Yasuhisa Ando Hideki Kamada Tsutomu Masaki Shigeo Takahashi Toru Shibata Yasuyuki Suzuki |
| author_sort | Minoru Oshima |
| collection | DOAJ |
| description | Abstract Background Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, the prognostic values of inflammatory nutritional scores were evaluated in the patients with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemoradiotherapy (NACRT). Methods A total of 49 patients who underwent pancreatectomy after NACRT from September 2009 to May 2016 were enrolled. The NACRT consisted of hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m2) delivered 5 days/week for 2 weeks before pancreatectomy. Inflammatory nutritional scores were determined before and after NACRT in this series. Results The median NLR increased after NACRT (from 2.067 to 3.302), with statistical difference (p < 0.001). In multivariate analysis, high pre-NACRT mGPS (2 or 1; p = 0.0478) and significant increase in CRP/Alb ratio after NACRT (≧ 0.077; p = 0.0036) were associated with shorter overall survival. All patients were divided into two groups according to the ΔCRP/Alb ratio after NACRT: the group with high ΔCRP/Alb ratio (≧ 0.077) and the group with low ΔCRP/Alb ratio (< 0.077). The group with high ΔCRP/Alb ratio after NACRT (n = 13) not only had higher post-NACRT CRP levels (p < 0.001) but also had lower post-NACRT Alb levels (p = 0.002). Patients in the group with high ΔCRP/Alb ratio lost more body weight during NACRT (p = 0.03). Conclusion In addition to pre-NACRT mGPS, ΔCRP/Alb after NACRT could provide prognostic value in the patients with PDAC treated by NACRT. |
| first_indexed | 2024-12-13T21:59:29Z |
| format | Article |
| id | doaj.art-2b218c3fe4794b76bf4c52e8befbb7f2 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T21:59:29Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-2b218c3fe4794b76bf4c52e8befbb7f22022-12-21T23:30:03ZengBMCBMC Gastroenterology1471-230X2020-12-0120111010.1186/s12876-020-01566-8Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancerMinoru Oshima0Keiichi Okano1Hironobu Suto2Yasuhisa Ando3Hideki Kamada4Tsutomu Masaki5Shigeo Takahashi6Toru Shibata7Yasuyuki Suzuki8Department of Gastroenterological Surgery, Faculty of Medicine, Kagawa UniversityDepartment of Gastroenterological Surgery, Faculty of Medicine, Kagawa UniversityDepartment of Gastroenterological Surgery, Faculty of Medicine, Kagawa UniversityDepartment of Gastroenterological Surgery, Faculty of Medicine, Kagawa UniversityDepartments of Gastroenterology and Neurology, Faculty of Medicine, Kagawa UniversityDepartments of Gastroenterology and Neurology, Faculty of Medicine, Kagawa UniversityRadiation Oncology, Faculty of Medicine, Kagawa UniversityRadiation Oncology, Faculty of Medicine, Kagawa UniversityDepartment of Gastroenterological Surgery, Faculty of Medicine, Kagawa UniversityAbstract Background Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in many types of cancer. In this study, the prognostic values of inflammatory nutritional scores were evaluated in the patients with resectable or borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemoradiotherapy (NACRT). Methods A total of 49 patients who underwent pancreatectomy after NACRT from September 2009 to May 2016 were enrolled. The NACRT consisted of hypofractionated external-beam radiotherapy (30 Gy in 10 fractions) with concurrent S-1 (60 mg/m2) delivered 5 days/week for 2 weeks before pancreatectomy. Inflammatory nutritional scores were determined before and after NACRT in this series. Results The median NLR increased after NACRT (from 2.067 to 3.302), with statistical difference (p < 0.001). In multivariate analysis, high pre-NACRT mGPS (2 or 1; p = 0.0478) and significant increase in CRP/Alb ratio after NACRT (≧ 0.077; p = 0.0036) were associated with shorter overall survival. All patients were divided into two groups according to the ΔCRP/Alb ratio after NACRT: the group with high ΔCRP/Alb ratio (≧ 0.077) and the group with low ΔCRP/Alb ratio (< 0.077). The group with high ΔCRP/Alb ratio after NACRT (n = 13) not only had higher post-NACRT CRP levels (p < 0.001) but also had lower post-NACRT Alb levels (p = 0.002). Patients in the group with high ΔCRP/Alb ratio lost more body weight during NACRT (p = 0.03). Conclusion In addition to pre-NACRT mGPS, ΔCRP/Alb after NACRT could provide prognostic value in the patients with PDAC treated by NACRT.https://doi.org/10.1186/s12876-020-01566-8Inflammatory nutritional factorPDACNACRT |
| spellingShingle | Minoru Oshima Keiichi Okano Hironobu Suto Yasuhisa Ando Hideki Kamada Tsutomu Masaki Shigeo Takahashi Toru Shibata Yasuyuki Suzuki Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer BMC Gastroenterology Inflammatory nutritional factor PDAC NACRT |
| title | Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| title_full | Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| title_fullStr | Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| title_full_unstemmed | Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| title_short | Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| title_sort | changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer |
| topic | Inflammatory nutritional factor PDAC NACRT |
| url | https://doi.org/10.1186/s12876-020-01566-8 |
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