Neutrophil stunning by metoprolol reduces infarct size
Metoprolol is a selective β1 adrenergic receptor blocker that reduces cardiac infarct size and improves cardiac function. The drug is believed to act on cardiomyocytes; however, here the authors show that metoprolol exerts its beneficial effect on infarcted heart by targeting neutrophils and alterin...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14780 |
| _version_ | 1819041961217097728 |
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| author | Jaime García-Prieto Rocío Villena-Gutiérrez Mónica Gómez Esther Bernardo Andrés Pun-García Inés García-Lunar Georgiana Crainiciuc Rodrigo Fernández-Jiménez Vinatha Sreeramkumar Rafael Bourio-Martínez José M García-Ruiz Alfonso Serrano del Valle David Sanz-Rosa Gonzalo Pizarro Antonio Fernández-Ortiz Andrés Hidalgo Valentín Fuster Borja Ibanez |
| author_facet | Jaime García-Prieto Rocío Villena-Gutiérrez Mónica Gómez Esther Bernardo Andrés Pun-García Inés García-Lunar Georgiana Crainiciuc Rodrigo Fernández-Jiménez Vinatha Sreeramkumar Rafael Bourio-Martínez José M García-Ruiz Alfonso Serrano del Valle David Sanz-Rosa Gonzalo Pizarro Antonio Fernández-Ortiz Andrés Hidalgo Valentín Fuster Borja Ibanez |
| author_sort | Jaime García-Prieto |
| collection | DOAJ |
| description | Metoprolol is a selective β1 adrenergic receptor blocker that reduces cardiac infarct size and improves cardiac function. The drug is believed to act on cardiomyocytes; however, here the authors show that metoprolol exerts its beneficial effect on infarcted heart by targeting neutrophils and altering their function and interaction with platelets. |
| first_indexed | 2024-12-21T09:33:18Z |
| format | Article |
| id | doaj.art-2b22a5e28d73475c92751f453e8cb4e3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:33:18Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2b22a5e28d73475c92751f453e8cb4e32022-12-21T19:08:41ZengNature PortfolioNature Communications2041-17232017-04-018111510.1038/ncomms14780Neutrophil stunning by metoprolol reduces infarct sizeJaime García-Prieto0Rocío Villena-Gutiérrez1Mónica Gómez2Esther Bernardo3Andrés Pun-García4Inés García-Lunar5Georgiana Crainiciuc6Rodrigo Fernández-Jiménez7Vinatha Sreeramkumar8Rafael Bourio-Martínez9José M García-Ruiz10Alfonso Serrano del Valle11David Sanz-Rosa12Gonzalo Pizarro13Antonio Fernández-Ortiz14Andrés Hidalgo15Valentín Fuster16Borja Ibanez17Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Hospital Clínico San CarlosCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)Metoprolol is a selective β1 adrenergic receptor blocker that reduces cardiac infarct size and improves cardiac function. The drug is believed to act on cardiomyocytes; however, here the authors show that metoprolol exerts its beneficial effect on infarcted heart by targeting neutrophils and altering their function and interaction with platelets.https://doi.org/10.1038/ncomms14780 |
| spellingShingle | Jaime García-Prieto Rocío Villena-Gutiérrez Mónica Gómez Esther Bernardo Andrés Pun-García Inés García-Lunar Georgiana Crainiciuc Rodrigo Fernández-Jiménez Vinatha Sreeramkumar Rafael Bourio-Martínez José M García-Ruiz Alfonso Serrano del Valle David Sanz-Rosa Gonzalo Pizarro Antonio Fernández-Ortiz Andrés Hidalgo Valentín Fuster Borja Ibanez Neutrophil stunning by metoprolol reduces infarct size Nature Communications |
| title | Neutrophil stunning by metoprolol reduces infarct size |
| title_full | Neutrophil stunning by metoprolol reduces infarct size |
| title_fullStr | Neutrophil stunning by metoprolol reduces infarct size |
| title_full_unstemmed | Neutrophil stunning by metoprolol reduces infarct size |
| title_short | Neutrophil stunning by metoprolol reduces infarct size |
| title_sort | neutrophil stunning by metoprolol reduces infarct size |
| url | https://doi.org/10.1038/ncomms14780 |
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