Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study
Abstract Aim The albumin‐indocyanine green evaluation (ALICE) score is a useful predictor of post‐hepatectomy liver failure (PHLF); however, its usefulness in combination with future liver remnant (FLR), measured by 3‐D volumetry, has not been investigated. This study aimed to investigate the relati...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Annals of Gastroenterological Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ags3.12743 |
| _version_ | 1827325609874817024 |
|---|---|
| author | Tomoyuki Nagaoka Kohei Ogawa Katsunori Sakamoto Taro Nakamura Yoshinori Imai Yusuke Nishi Masahiko Honjo Kei Tamura Naotake Funamizu Yasutsugu Takada |
| author_facet | Tomoyuki Nagaoka Kohei Ogawa Katsunori Sakamoto Taro Nakamura Yoshinori Imai Yusuke Nishi Masahiko Honjo Kei Tamura Naotake Funamizu Yasutsugu Takada |
| author_sort | Tomoyuki Nagaoka |
| collection | DOAJ |
| description | Abstract Aim The albumin‐indocyanine green evaluation (ALICE) score is a useful predictor of post‐hepatectomy liver failure (PHLF); however, its usefulness in combination with future liver remnant (FLR), measured by 3‐D volumetry, has not been investigated. This study aimed to investigate the relationship between the ALICE of the FLR (ALICE‐FLR) score and severe PHLF. Methods The clinical data of 215 patients who underwent anatomical hepatectomy for hepatocellular carcinoma without portal vein embolization at two institutes between January 2010 and December 2021 were analyzed retrospectively. PHLF occurrence and severity were determined according to the International Study Group of Liver Surgery's definition. Grades B and C PHLF were defined as severe PHLF. The ALICE‐FLR, ALICE scores, and indocyanine green clearance of FLR (ICGK‐FLR) were evaluated for severe PHLF prediction. Results Severe PHLF was observed in 40 patients (18.6%). The areas under the curve (AUCs) for the ALICE‐FLR, ALICE scores, ICGK‐FLR, and FLR were 0.76, 0.64, 0.73, and 0.69, respectively. The AUC of the ALICE‐FLR score was significantly higher than that of the ALICE score. The ALICE‐FLR score was identified as an independent predictor of severe PHLF (the odds ratio for every 0.01 increment in the ALICE‐FLR score was 1.24; 95% confidence interval, 1.070–1.453; p = 0.004). Among patients with severe PHLF, the ALICE‐FLR score was significantly higher in the grade C than in the grade B PHLF group. Conclusion The combination of liver function models, including indocyanine green, albumin, and FLR is considered compatible for predicting severe PHLF. |
| first_indexed | 2024-03-07T14:31:44Z |
| format | Article |
| id | doaj.art-2b236ef41a344a35af90ac9371d7d3d0 |
| institution | Directory Open Access Journal |
| issn | 2475-0328 |
| language | English |
| last_indexed | 2024-03-07T14:31:44Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj.art-2b236ef41a344a35af90ac9371d7d3d02024-03-06T03:47:05ZengWileyAnnals of Gastroenterological Surgery2475-03282024-03-018229330010.1002/ags3.12743Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective studyTomoyuki Nagaoka0Kohei Ogawa1Katsunori Sakamoto2Taro Nakamura3Yoshinori Imai4Yusuke Nishi5Masahiko Honjo6Kei Tamura7Naotake Funamizu8Yasutsugu Takada9Department of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic Surgery Uwajima City Hospital Uwajima JapanDepartment of General Surgery Uwajima City Hospital Uwajima JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanDepartment of Hepato‐Biliary‐Pancreatic and Breast Surgery Ehime University Graduate School of Medicine Toon JapanAbstract Aim The albumin‐indocyanine green evaluation (ALICE) score is a useful predictor of post‐hepatectomy liver failure (PHLF); however, its usefulness in combination with future liver remnant (FLR), measured by 3‐D volumetry, has not been investigated. This study aimed to investigate the relationship between the ALICE of the FLR (ALICE‐FLR) score and severe PHLF. Methods The clinical data of 215 patients who underwent anatomical hepatectomy for hepatocellular carcinoma without portal vein embolization at two institutes between January 2010 and December 2021 were analyzed retrospectively. PHLF occurrence and severity were determined according to the International Study Group of Liver Surgery's definition. Grades B and C PHLF were defined as severe PHLF. The ALICE‐FLR, ALICE scores, and indocyanine green clearance of FLR (ICGK‐FLR) were evaluated for severe PHLF prediction. Results Severe PHLF was observed in 40 patients (18.6%). The areas under the curve (AUCs) for the ALICE‐FLR, ALICE scores, ICGK‐FLR, and FLR were 0.76, 0.64, 0.73, and 0.69, respectively. The AUC of the ALICE‐FLR score was significantly higher than that of the ALICE score. The ALICE‐FLR score was identified as an independent predictor of severe PHLF (the odds ratio for every 0.01 increment in the ALICE‐FLR score was 1.24; 95% confidence interval, 1.070–1.453; p = 0.004). Among patients with severe PHLF, the ALICE‐FLR score was significantly higher in the grade C than in the grade B PHLF group. Conclusion The combination of liver function models, including indocyanine green, albumin, and FLR is considered compatible for predicting severe PHLF.https://doi.org/10.1002/ags3.12743albuminhepatectomyhepatocellular carcinomaindocyanine greenliver failure |
| spellingShingle | Tomoyuki Nagaoka Kohei Ogawa Katsunori Sakamoto Taro Nakamura Yoshinori Imai Yusuke Nishi Masahiko Honjo Kei Tamura Naotake Funamizu Yasutsugu Takada Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study Annals of Gastroenterological Surgery albumin hepatectomy hepatocellular carcinoma indocyanine green liver failure |
| title | Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study |
| title_full | Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study |
| title_fullStr | Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study |
| title_full_unstemmed | Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study |
| title_short | Albumin‐indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma: A dual‐center retrospective study |
| title_sort | albumin indocyanine green evaluation of future liver remnant predicts liver failure after anatomical hepatectomy for hepatocellular carcinoma a dual center retrospective study |
| topic | albumin hepatectomy hepatocellular carcinoma indocyanine green liver failure |
| url | https://doi.org/10.1002/ags3.12743 |
| work_keys_str_mv | AT tomoyukinagaoka albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT koheiogawa albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT katsunorisakamoto albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT taronakamura albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT yoshinoriimai albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT yusukenishi albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT masahikohonjo albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT keitamura albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT naotakefunamizu albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy AT yasutsugutakada albuminindocyaninegreenevaluationoffutureliverremnantpredictsliverfailureafteranatomicalhepatectomyforhepatocellularcarcinomaadualcenterretrospectivestudy |