Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/5/458 |
| _version_ | 1818540450593636352 |
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| author | Ruikun Du Qinghua Cui Lijun Rong |
| author_facet | Ruikun Du Qinghua Cui Lijun Rong |
| author_sort | Ruikun Du |
| collection | DOAJ |
| description | The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry. |
| first_indexed | 2024-12-11T21:55:31Z |
| format | Article |
| id | doaj.art-2b24ecaffafc4eb6a4ef514b2912c5e0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T21:55:31Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-2b24ecaffafc4eb6a4ef514b2912c5e02022-12-22T00:49:19ZengMDPI AGViruses1999-49152019-05-0111545810.3390/v11050458v11050458Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus EntryRuikun Du0Qinghua Cui1Lijun Rong2College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaDepartment of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USAThe hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry.https://www.mdpi.com/1999-4915/11/5/458influenza A virushemagglutininneuraminidasevirus entry |
| spellingShingle | Ruikun Du Qinghua Cui Lijun Rong Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry Viruses influenza A virus hemagglutinin neuraminidase virus entry |
| title | Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry |
| title_full | Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry |
| title_fullStr | Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry |
| title_full_unstemmed | Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry |
| title_short | Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry |
| title_sort | competitive cooperation of hemagglutinin and neuraminidase during influenza a virus entry |
| topic | influenza A virus hemagglutinin neuraminidase virus entry |
| url | https://www.mdpi.com/1999-4915/11/5/458 |
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