Sirtuins and diabetes: optimizing the sweetness in the blood
Abstract Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the people for this disease is age independent. However, sirtuins, which get activate typ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Translational Medicine Communications |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41231-019-0034-7 |
| _version_ | 1818974703590572032 |
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| author | Abhinav Kanwal Liston Augustine Dsouza |
| author_facet | Abhinav Kanwal Liston Augustine Dsouza |
| author_sort | Abhinav Kanwal |
| collection | DOAJ |
| description | Abstract Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the people for this disease is age independent. However, sirtuins, which get activate typically during calorie restriction plays a pivotal role in optimizing effect of blood glucose levels in diabetic patients. Among different sirtuin homologs, some of the sirtuins are known for regulating pathophysiology of diabetic condition. Still the role of other sirtuins in understanding the function and regulatory mechanism in DM is still emerging. In this review, we focused on recent studies which help us to understand about the role of sirtuins and how they regulate the pathophysiology in diabetic condition. |
| first_indexed | 2024-12-20T15:44:16Z |
| format | Article |
| id | doaj.art-2b25145d9dc04152b40d91562a2c5e6b |
| institution | Directory Open Access Journal |
| issn | 2396-832X |
| language | English |
| last_indexed | 2024-12-20T15:44:16Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Medicine Communications |
| spelling | doaj.art-2b25145d9dc04152b40d91562a2c5e6b2022-12-21T19:35:02ZengBMCTranslational Medicine Communications2396-832X2019-02-01411810.1186/s41231-019-0034-7Sirtuins and diabetes: optimizing the sweetness in the bloodAbhinav Kanwal0Liston Augustine Dsouza1Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher EducationManipal College of Pharmaceutical Sciences, Manipal Academy of Higher EducationAbstract Diabetes Mellitus (DM) is a chronic disease characterized by elevated levels of glucose in the blood. With time it becomes uncontrollable and invites other complex metabolic diseases. The propensity of the people for this disease is age independent. However, sirtuins, which get activate typically during calorie restriction plays a pivotal role in optimizing effect of blood glucose levels in diabetic patients. Among different sirtuin homologs, some of the sirtuins are known for regulating pathophysiology of diabetic condition. Still the role of other sirtuins in understanding the function and regulatory mechanism in DM is still emerging. In this review, we focused on recent studies which help us to understand about the role of sirtuins and how they regulate the pathophysiology in diabetic condition.http://link.springer.com/article/10.1186/s41231-019-0034-7SirtuinsDiabetesDiseasesMitochondriaExerciseDeacetylation |
| spellingShingle | Abhinav Kanwal Liston Augustine Dsouza Sirtuins and diabetes: optimizing the sweetness in the blood Translational Medicine Communications Sirtuins Diabetes Diseases Mitochondria Exercise Deacetylation |
| title | Sirtuins and diabetes: optimizing the sweetness in the blood |
| title_full | Sirtuins and diabetes: optimizing the sweetness in the blood |
| title_fullStr | Sirtuins and diabetes: optimizing the sweetness in the blood |
| title_full_unstemmed | Sirtuins and diabetes: optimizing the sweetness in the blood |
| title_short | Sirtuins and diabetes: optimizing the sweetness in the blood |
| title_sort | sirtuins and diabetes optimizing the sweetness in the blood |
| topic | Sirtuins Diabetes Diseases Mitochondria Exercise Deacetylation |
| url | http://link.springer.com/article/10.1186/s41231-019-0034-7 |
| work_keys_str_mv | AT abhinavkanwal sirtuinsanddiabetesoptimizingthesweetnessintheblood AT listonaugustinedsouza sirtuinsanddiabetesoptimizingthesweetnessintheblood |