Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye
<strong>Objective: </strong>Acute and chronic ethanol consumption cause oxidative stress and ginger improves suchconditions. In this study, the protective effects of ginger were studied on indices of oxidative stress, total homocysteinelevel and the level of the some of the oxidative str...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-07-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_14330_69957eee48df32aa53911a911df66146.pdf |
| _version_ | 1818597437518905344 |
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| author | Abolfazl Akbari Khadijeh Nasiri Mojtaba Heydari |
| author_facet | Abolfazl Akbari Khadijeh Nasiri Mojtaba Heydari |
| author_sort | Abolfazl Akbari |
| collection | DOAJ |
| description | <strong>Objective: </strong>Acute and chronic ethanol consumption cause oxidative stress and ginger improves suchconditions. In this study, the protective effects of ginger were studied on indices of oxidative stress, total homocysteinelevel and the level of the some of the oxidative stress-associated trace elements against toxicity induced by ethanol in rat eye.<br /> <strong>Materials and Methods:</strong>Twenty-four adult male Sprague-Dawley rats were randomly allocated into four groups and treated daily for 28 days as follows: group I: control;group II: ginger (1g/kg/day ginger extract by oral gavage); group III: ethanol (4g/kg/day ethanol by oral gavage) and group IV: ginger+ethanol. At the end of the experimental period, eye tissue sera were used for determination of different parameters. Furthermore, <em>in vitro</em> antioxidant potential and total phenol content of ginger extract were determined.<br /> <strong>Results: </strong>In ethanol group, significant changes in oxidative stress markers and levels of homocysteine and some trace elements, compared to other groups, were observed (p <strong>Conclusion: </strong>It can be concluded that ginger extract has protective effects against toxicity induced by ethanol in the eye of male rat. |
| first_indexed | 2024-12-16T11:47:48Z |
| format | Article |
| id | doaj.art-2b25b24afe1c4ea58ff55204386520c2 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-16T11:47:48Z |
| publishDate | 2020-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-2b25b24afe1c4ea58ff55204386520c22022-12-21T22:32:47ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492020-07-0110436537110.22038/ajp.2019.1433014330Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eyeAbolfazl Akbari0Khadijeh Nasiri1Mojtaba Heydari2Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, IranPoostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran<strong>Objective: </strong>Acute and chronic ethanol consumption cause oxidative stress and ginger improves suchconditions. In this study, the protective effects of ginger were studied on indices of oxidative stress, total homocysteinelevel and the level of the some of the oxidative stress-associated trace elements against toxicity induced by ethanol in rat eye.<br /> <strong>Materials and Methods:</strong>Twenty-four adult male Sprague-Dawley rats were randomly allocated into four groups and treated daily for 28 days as follows: group I: control;group II: ginger (1g/kg/day ginger extract by oral gavage); group III: ethanol (4g/kg/day ethanol by oral gavage) and group IV: ginger+ethanol. At the end of the experimental period, eye tissue sera were used for determination of different parameters. Furthermore, <em>in vitro</em> antioxidant potential and total phenol content of ginger extract were determined.<br /> <strong>Results: </strong>In ethanol group, significant changes in oxidative stress markers and levels of homocysteine and some trace elements, compared to other groups, were observed (p <strong>Conclusion: </strong>It can be concluded that ginger extract has protective effects against toxicity induced by ethanol in the eye of male rat.http://ajp.mums.ac.ir/article_14330_69957eee48df32aa53911a911df66146.pdfeyeethanolgingeroxidative stresshomocysteinetrace elementzingiber officinale roscoe |
| spellingShingle | Abolfazl Akbari Khadijeh Nasiri Mojtaba Heydari Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye Avicenna Journal of Phytomedicine eye ethanol ginger oxidative stress homocysteine trace element zingiber officinale roscoe |
| title | Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| title_full | Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| title_fullStr | Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| title_full_unstemmed | Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| title_short | Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| title_sort | ginger zingiber officinale roscoe extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye |
| topic | eye ethanol ginger oxidative stress homocysteine trace element zingiber officinale roscoe |
| url | http://ajp.mums.ac.ir/article_14330_69957eee48df32aa53911a911df66146.pdf |
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