Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei
Quantitative Susceptibility Mapping (QSM) is a recent MRI-technique able to quantify the bulk magnetic susceptibility of myelin, iron, and calcium in the brain. Its variability across different acquisition parameters has prompted the need for standardisation across multiple centres and MRI vendors....
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923004238 |
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| author | Valentina Bordin Alice Pirastru Niels Bergsland Marta Cazzoli Giuseppe Baselli Francesca Baglio |
| author_facet | Valentina Bordin Alice Pirastru Niels Bergsland Marta Cazzoli Giuseppe Baselli Francesca Baglio |
| author_sort | Valentina Bordin |
| collection | DOAJ |
| description | Quantitative Susceptibility Mapping (QSM) is a recent MRI-technique able to quantify the bulk magnetic susceptibility of myelin, iron, and calcium in the brain. Its variability across different acquisition parameters has prompted the need for standardisation across multiple centres and MRI vendors. However, a high level of agreement between repeated imaging acquisitions is equally important. With this study we aimed to assess the inter-scan repeatability of an optimised multi-echo GRE sequence in 28 healthy volunteers. We extracted and compared the susceptibility measures from the scan and rescan acquisitions across 7 bilateral brain regions (i.e., 14 regions of interest (ROIs)) relevant for neurodegeneration. Repeatability was first assessed while reconstructing QSM with a fixed number of echo times (i.e., 8). Excellent inter-scan repeatability was found for putamen, globus pallidus and caudate nucleus, while good performance characterised the remaining structures. An increased variability was instead noted for small ROIs like red nucleus and substantia nigra. Secondly, we assessed the impact exerted on repeatability by the number of echoes used to derive QSM maps. Results were impacted by this parameter, especially in smaller regions. Larger brain structures, on the other hand, showed more consistent performance. Nevertheless, with either 8 or 7 echoes we managed to obtain good inter-scan repeatability on almost all ROIs. These findings indicate that the designed acquisition/reconstruction protocol has wide applicability, particularly in clinical or research settings involving longitudinal acquisitions (e.g. rehabilitation studies). |
| first_indexed | 2024-03-12T15:08:01Z |
| format | Article |
| id | doaj.art-2b261c6f31624ce5a84c3d2c3cb040ab |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-03-12T15:08:01Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-2b261c6f31624ce5a84c3d2c3cb040ab2023-08-12T04:33:47ZengElsevierNeuroImage1095-95722023-09-01278120272Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nucleiValentina Bordin0Alice Pirastru1Niels Bergsland2Marta Cazzoli3Giuseppe Baselli4Francesca Baglio5Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; Corresponding author at: Department of Electronics, Information and Bioengineering, Politecnico di Milano, Via Camillo Golgi 39, 20133 Milan, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy; Department of Neurology, Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United StatesIRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, ItalyDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, ItalyIRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, ItalyQuantitative Susceptibility Mapping (QSM) is a recent MRI-technique able to quantify the bulk magnetic susceptibility of myelin, iron, and calcium in the brain. Its variability across different acquisition parameters has prompted the need for standardisation across multiple centres and MRI vendors. However, a high level of agreement between repeated imaging acquisitions is equally important. With this study we aimed to assess the inter-scan repeatability of an optimised multi-echo GRE sequence in 28 healthy volunteers. We extracted and compared the susceptibility measures from the scan and rescan acquisitions across 7 bilateral brain regions (i.e., 14 regions of interest (ROIs)) relevant for neurodegeneration. Repeatability was first assessed while reconstructing QSM with a fixed number of echo times (i.e., 8). Excellent inter-scan repeatability was found for putamen, globus pallidus and caudate nucleus, while good performance characterised the remaining structures. An increased variability was instead noted for small ROIs like red nucleus and substantia nigra. Secondly, we assessed the impact exerted on repeatability by the number of echoes used to derive QSM maps. Results were impacted by this parameter, especially in smaller regions. Larger brain structures, on the other hand, showed more consistent performance. Nevertheless, with either 8 or 7 echoes we managed to obtain good inter-scan repeatability on almost all ROIs. These findings indicate that the designed acquisition/reconstruction protocol has wide applicability, particularly in clinical or research settings involving longitudinal acquisitions (e.g. rehabilitation studies).http://www.sciencedirect.com/science/article/pii/S1053811923004238Magnetic resonance imagingQuantitative susceptibility mappingRepeatabilityBasal gangliaSubcortical brain nucleiRehabilitation study |
| spellingShingle | Valentina Bordin Alice Pirastru Niels Bergsland Marta Cazzoli Giuseppe Baselli Francesca Baglio Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei NeuroImage Magnetic resonance imaging Quantitative susceptibility mapping Repeatability Basal ganglia Subcortical brain nuclei Rehabilitation study |
| title | Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei |
| title_full | Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei |
| title_fullStr | Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei |
| title_full_unstemmed | Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei |
| title_short | Optimal echo times for quantitative susceptibility mapping: A test-retest study on basal ganglia and subcortical brain nuclei |
| title_sort | optimal echo times for quantitative susceptibility mapping a test retest study on basal ganglia and subcortical brain nuclei |
| topic | Magnetic resonance imaging Quantitative susceptibility mapping Repeatability Basal ganglia Subcortical brain nuclei Rehabilitation study |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923004238 |
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