Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies
No consensus has yet been reached on the associations of lipid variability (LV) with cardiovascular diseases (CVDs) and all-cause mortality. We aimed to quantify the associations of different types and metrics of LV with CVDs and all-cause mortality. PubMed, Medline, and Embase databases were search...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/12/2450 |
| _version_ | 1797483653391974400 |
|---|---|
| author | Shuting Li Leying Hou Siyu Zhu Qian Yi Wen Liu Yang Zhao Feitong Wu Xue Li An Pan Peige Song |
| author_facet | Shuting Li Leying Hou Siyu Zhu Qian Yi Wen Liu Yang Zhao Feitong Wu Xue Li An Pan Peige Song |
| author_sort | Shuting Li |
| collection | DOAJ |
| description | No consensus has yet been reached on the associations of lipid variability (LV) with cardiovascular diseases (CVDs) and all-cause mortality. We aimed to quantify the associations of different types and metrics of LV with CVDs and all-cause mortality. PubMed, Medline, and Embase databases were searched for eligible cohort studies published until 14 December 2021. Lipids included total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Metrics of variability included standard deviation (SD), coefficient of variation (CV), and variation independent of the mean (VIM). The primary outcomes were CVDs and all-cause mortality. Random-effects meta-analysis was used to generate a summary of the relative risks (SRRs). Sources of heterogeneity were explored by subgroup analysis and meta-regression. A total of 11 articles based on seven cohorts were included. Participants in the top quartile of TC variability had an increased risk of CVDs (vs. bottom quartile: TC-CV: SRR 1.29, 95% CI 1.15-1.45; TC-SD: 1.28, 1.15–1.43; TC-VIM: 1.26, 1.13–1.41, respectively) and all-cause mortality (vs. bottom quartile: TC-CV: 1.28, 1.15–1.42; TC-SD: 1.32, 1.22–1.44; TC-VIM: 1.32, 1.25–1.40, respectively). Participants in the top quartile of HDL-C variability had an increased risk of CVDs (vs. bottom quartile: HDL-C-CV: 1.11, 1.07–1.15; HDL-C-SD: 1.18, 1.02–1.38; HDL-C-VIM: 1.18, 1.09–1.27, respectively) and all-cause mortality (vs. bottom quartile: HDL-C-CV: 1.29, 1.27–1.31; HDL-C-SD: 1.24, 1.09–1.41; HDL-C-VIM: 1.25, 1.22–1.27, respectively). LDL-C variability was also associated with an increased risk of CVDs (for top vs. bottom quartile; LDL-C-SD: 1.09, 1.02–1.17; LDL-C-VIM: 1.16, 1.02–1.32, respectively) and all-cause mortality (for top vs. bottom quartile; LDL-C-CV: 1.19, 1.04–1.36; LDL-C-SD: 1.17, 1.09–1.26, respectively). The relationships of TG variability with the risk of CVDs and all-cause mortality were inconclusive across different metrics. The effects of SRR became stronger when analyses were restricted to studies that adjusted for lipid-lowering medication and unadjusted for mean lipid levels. These findings indicate that the measurement and surveillance of lipid variability might have important clinical implications for risk assessment of CVDs and all-cause mortality. |
| first_indexed | 2024-03-09T22:50:05Z |
| format | Article |
| id | doaj.art-2b2640c60bf84512ba24b6c6fd5e2a0e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:50:05Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2b2640c60bf84512ba24b6c6fd5e2a0e2023-11-23T18:21:18ZengMDPI AGNutrients2072-66432022-06-011412245010.3390/nu14122450Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort StudiesShuting Li0Leying Hou1Siyu Zhu2Qian Yi3Wen Liu4Yang Zhao5Feitong Wu6Xue Li7An Pan8Peige Song9School of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaSchool of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaSchool of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaSchool of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaSchool of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaThe George Institute for Global Health, University of New South Wales, Sydney, NSW 2050, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, AustraliaSchool of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaMinistry of Education Key Laboratory of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, ChinaSchool of Public Health and Women’s Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, ChinaNo consensus has yet been reached on the associations of lipid variability (LV) with cardiovascular diseases (CVDs) and all-cause mortality. We aimed to quantify the associations of different types and metrics of LV with CVDs and all-cause mortality. PubMed, Medline, and Embase databases were searched for eligible cohort studies published until 14 December 2021. Lipids included total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Metrics of variability included standard deviation (SD), coefficient of variation (CV), and variation independent of the mean (VIM). The primary outcomes were CVDs and all-cause mortality. Random-effects meta-analysis was used to generate a summary of the relative risks (SRRs). Sources of heterogeneity were explored by subgroup analysis and meta-regression. A total of 11 articles based on seven cohorts were included. Participants in the top quartile of TC variability had an increased risk of CVDs (vs. bottom quartile: TC-CV: SRR 1.29, 95% CI 1.15-1.45; TC-SD: 1.28, 1.15–1.43; TC-VIM: 1.26, 1.13–1.41, respectively) and all-cause mortality (vs. bottom quartile: TC-CV: 1.28, 1.15–1.42; TC-SD: 1.32, 1.22–1.44; TC-VIM: 1.32, 1.25–1.40, respectively). Participants in the top quartile of HDL-C variability had an increased risk of CVDs (vs. bottom quartile: HDL-C-CV: 1.11, 1.07–1.15; HDL-C-SD: 1.18, 1.02–1.38; HDL-C-VIM: 1.18, 1.09–1.27, respectively) and all-cause mortality (vs. bottom quartile: HDL-C-CV: 1.29, 1.27–1.31; HDL-C-SD: 1.24, 1.09–1.41; HDL-C-VIM: 1.25, 1.22–1.27, respectively). LDL-C variability was also associated with an increased risk of CVDs (for top vs. bottom quartile; LDL-C-SD: 1.09, 1.02–1.17; LDL-C-VIM: 1.16, 1.02–1.32, respectively) and all-cause mortality (for top vs. bottom quartile; LDL-C-CV: 1.19, 1.04–1.36; LDL-C-SD: 1.17, 1.09–1.26, respectively). The relationships of TG variability with the risk of CVDs and all-cause mortality were inconclusive across different metrics. The effects of SRR became stronger when analyses were restricted to studies that adjusted for lipid-lowering medication and unadjusted for mean lipid levels. These findings indicate that the measurement and surveillance of lipid variability might have important clinical implications for risk assessment of CVDs and all-cause mortality.https://www.mdpi.com/2072-6643/14/12/2450lipid variabilitycardiovascular diseasesmortalitymeta-analysis |
| spellingShingle | Shuting Li Leying Hou Siyu Zhu Qian Yi Wen Liu Yang Zhao Feitong Wu Xue Li An Pan Peige Song Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies Nutrients lipid variability cardiovascular diseases mortality meta-analysis |
| title | Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies |
| title_full | Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies |
| title_fullStr | Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies |
| title_full_unstemmed | Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies |
| title_short | Lipid Variability and Risk of Cardiovascular Diseases and All-Cause Mortality: A Systematic Review and Meta-Analysis of Cohort Studies |
| title_sort | lipid variability and risk of cardiovascular diseases and all cause mortality a systematic review and meta analysis of cohort studies |
| topic | lipid variability cardiovascular diseases mortality meta-analysis |
| url | https://www.mdpi.com/2072-6643/14/12/2450 |
| work_keys_str_mv | AT shutingli lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT leyinghou lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT siyuzhu lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT qianyi lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT wenliu lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT yangzhao lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT feitongwu lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT xueli lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT anpan lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies AT peigesong lipidvariabilityandriskofcardiovasculardiseasesandallcausemortalityasystematicreviewandmetaanalysisofcohortstudies |