Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surfac...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2018-12-01
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| Series: | Cellular Physiology and Biochemistry |
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| Online Access: | https://www.karger.com/Article/FullText/495897 |
| _version_ | 1818192221384474624 |
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| author | Shi-fang Li Mei-jiao Gong Fu-rong Zhao Jun-jun Shao Yin-li Xie Yong-guang Zhang Hui-yun Chang |
| author_facet | Shi-fang Li Mei-jiao Gong Fu-rong Zhao Jun-jun Shao Yin-li Xie Yong-guang Zhang Hui-yun Chang |
| author_sort | Shi-fang Li |
| collection | DOAJ |
| description | The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses. |
| first_indexed | 2024-12-12T00:27:03Z |
| format | Article |
| id | doaj.art-2b28bc7a1a95433f99953e6130d675c7 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-12T00:27:03Z |
| publishDate | 2018-12-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-2b28bc7a1a95433f99953e6130d675c72022-12-22T00:44:35ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782018-12-015152377239610.1159/000495897495897Type I Interferons: Distinct Biological Activities and Current Applications for Viral InfectionShi-fang LiMei-jiao GongFu-rong ZhaoJun-jun ShaoYin-li XieYong-guang ZhangHui-yun ChangThe interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.https://www.karger.com/Article/FullText/495897Type I IFN classesAntiviralViral infectionImmunodeficiency virusHepatitisInfluenza Virus |
| spellingShingle | Shi-fang Li Mei-jiao Gong Fu-rong Zhao Jun-jun Shao Yin-li Xie Yong-guang Zhang Hui-yun Chang Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection Cellular Physiology and Biochemistry Type I IFN classes Antiviral Viral infection Immunodeficiency virus Hepatitis Influenza Virus |
| title | Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection |
| title_full | Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection |
| title_fullStr | Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection |
| title_full_unstemmed | Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection |
| title_short | Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection |
| title_sort | type i interferons distinct biological activities and current applications for viral infection |
| topic | Type I IFN classes Antiviral Viral infection Immunodeficiency virus Hepatitis Influenza Virus |
| url | https://www.karger.com/Article/FullText/495897 |
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