Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT<sub>1A</sub> Ligands: Binding and Docking Studies

Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT<sub>1A</sub> Ligands: Binding and Docking Studies

Trazodone, a well-known antidepressant drug widely used throughout the world, works as a 5-hydroxytryptamine (5-HT<sub>2</sub>) and &#945;<sub>1</sub>-adrenergic receptor antagonist and a serotonin reuptake inhibitor. Our research aimed to develop a new method for the syn...

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Bibliographic Details
Main Authors: Jolanta Jaśkowska, Przemysław Zaręba, Paweł Śliwa, Edyta Pindelska, Grzegorz Satała, Zbigniew Majka
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
trazodone derivatives
trazodone synthesis
microwave (MW)-assisted synthesis
serotonin receptor ligands
5-HT<sub>1A</sub> ligands
long-chain arylpiperazines
Online Access:https://www.mdpi.com/1420-3049/24/8/1609

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https://www.mdpi.com/1420-3049/24/8/1609

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