Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection
Multidrug-resistant (MDR) Acinetobacter baumannii (Acb) is a rapidly emerging pathogen in healthcare settings. The aim of this study was to evaluate the predictors of poor outcome in patients with MDR Acb. This is the first report documenting factors influencing survival in patients with MDR Acb in...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300004&lng=en&tlng=en |
| _version_ | 1811288329693429760 |
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| author | Mariana Lima Prata-Rocha Paulo Pinto Gontijo-Filho Geraldo Batista de Melo |
| author_facet | Mariana Lima Prata-Rocha Paulo Pinto Gontijo-Filho Geraldo Batista de Melo |
| author_sort | Mariana Lima Prata-Rocha |
| collection | DOAJ |
| description | Multidrug-resistant (MDR) Acinetobacter baumannii (Acb) is a rapidly emerging pathogen in healthcare settings. The aim of this study was to evaluate the predictors of poor outcome in patients with MDR Acb. This is the first report documenting factors influencing survival in patients with MDR Acb in this tertiary hospital. This study is a prospective of the hospital epidemiology database. A total of 73 patients with 84 Acb isolates were obtained between August 2009 and October 2010 in this hospital. In the present study, the 30-day mortality rate was 39.7%. Of 84 Acb isolates, 50 (59%) were MDR, nine (11%) were pan-resistant, and 25 (30%) were non-MDR. The non-MDR isolates were used as the control group. The factors significantly associated with multidrug resistance included previous surgeries, presence of comorbidity (renal disease), use of more than two devices, parenteral nutrition, and inappropriate antimicrobial therapy. Significant predictors of 30-day mortality in the univariate analysis included pneumonia, diabetes mellitus, renal disease, use of more than two devices, and inappropriate antimicrobial therapy administered within two days of the onset of infection. The factors associated with mortality in patients with MDR Acb infection in this study were: age > 60 years, pneumonia, diabetes mellitus, renal disease, use of more than two invasive procedures, and inappropriate antimicrobial therapy. Vigilance is needed to prevent outbreaks of this opportunistic and deadly pathogen. |
| first_indexed | 2024-04-13T03:34:38Z |
| format | Article |
| id | doaj.art-2b2b18e8e0c64297915773ef94dd92c8 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-04-13T03:34:38Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-2b2b18e8e0c64297915773ef94dd92c82022-12-22T03:04:21ZengElsevierBrazilian Journal of Infectious Diseases1678-439116323724110.1590/S1413-86702012000300004S1413-86702012000300004Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infectionMariana Lima Prata-Rocha0Paulo Pinto Gontijo-Filho1Geraldo Batista de Melo2Universidade Federal de UberlândiaUniversidade Federal de UberlândiaUniversidade Federal de UberlândiaMultidrug-resistant (MDR) Acinetobacter baumannii (Acb) is a rapidly emerging pathogen in healthcare settings. The aim of this study was to evaluate the predictors of poor outcome in patients with MDR Acb. This is the first report documenting factors influencing survival in patients with MDR Acb in this tertiary hospital. This study is a prospective of the hospital epidemiology database. A total of 73 patients with 84 Acb isolates were obtained between August 2009 and October 2010 in this hospital. In the present study, the 30-day mortality rate was 39.7%. Of 84 Acb isolates, 50 (59%) were MDR, nine (11%) were pan-resistant, and 25 (30%) were non-MDR. The non-MDR isolates were used as the control group. The factors significantly associated with multidrug resistance included previous surgeries, presence of comorbidity (renal disease), use of more than two devices, parenteral nutrition, and inappropriate antimicrobial therapy. Significant predictors of 30-day mortality in the univariate analysis included pneumonia, diabetes mellitus, renal disease, use of more than two devices, and inappropriate antimicrobial therapy administered within two days of the onset of infection. The factors associated with mortality in patients with MDR Acb infection in this study were: age > 60 years, pneumonia, diabetes mellitus, renal disease, use of more than two invasive procedures, and inappropriate antimicrobial therapy. Vigilance is needed to prevent outbreaks of this opportunistic and deadly pathogen.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300004&lng=en&tlng=enmultidrug-resistantAcinetobacter baumanniigram-negative bacteria |
| spellingShingle | Mariana Lima Prata-Rocha Paulo Pinto Gontijo-Filho Geraldo Batista de Melo Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection Brazilian Journal of Infectious Diseases multidrug-resistant Acinetobacter baumannii gram-negative bacteria |
| title | Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection |
| title_full | Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection |
| title_fullStr | Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection |
| title_full_unstemmed | Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection |
| title_short | Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection |
| title_sort | factors influencing survival in patients with multidrug resistant acinetobacter baumannii infection |
| topic | multidrug-resistant Acinetobacter baumannii gram-negative bacteria |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300004&lng=en&tlng=en |
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