Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1
In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete <i>Amycolatopsis</i> sp. WP1, yielded six novel amycolachromones A–F (<b>1</b>–<b>6</b>), together with five known analogues (<b>7</b&...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/3/162 |
| Summary: | In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete <i>Amycolatopsis</i> sp. WP1, yielded six novel amycolachromones A–F (<b>1</b>–<b>6</b>), together with five known analogues (<b>7</b>–<b>11</b>). Amycolachromones A–B (<b>1</b>–<b>2</b>) possessed unique dimer skeletons. The structures and relative configurations of compounds <b>1</b>–<b>11</b> were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed. |
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| ISSN: | 1660-3397 |