Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1
In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete <i>Amycolatopsis</i> sp. WP1, yielded six novel amycolachromones A–F (<b>1</b>–<b>6</b>), together with five known analogues (<b>7</b&...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/3/162 |
| _version_ | 1797445791375163392 |
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| author | Jianwei Chen Jun Chen Siqi Wang Xiaoze Bao Songwei Li Bin Wei Huawei Zhang Hong Wang |
| author_facet | Jianwei Chen Jun Chen Siqi Wang Xiaoze Bao Songwei Li Bin Wei Huawei Zhang Hong Wang |
| author_sort | Jianwei Chen |
| collection | DOAJ |
| description | In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete <i>Amycolatopsis</i> sp. WP1, yielded six novel amycolachromones A–F (<b>1</b>–<b>6</b>), together with five known analogues (<b>7</b>–<b>11</b>). Amycolachromones A–B (<b>1</b>–<b>2</b>) possessed unique dimer skeletons. The structures and relative configurations of compounds <b>1</b>–<b>11</b> were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed. |
| first_indexed | 2024-03-09T13:30:55Z |
| format | Article |
| id | doaj.art-2b2e7e3b571945799be69ecf250ecb54 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T13:30:55Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-2b2e7e3b571945799be69ecf250ecb542023-11-30T21:17:41ZengMDPI AGMarine Drugs1660-33972022-02-0120316210.3390/md20030162Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1Jianwei Chen0Jun Chen1Siqi Wang2Xiaoze Bao3Songwei Li4Bin Wei5Huawei Zhang6Hong Wang7College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu’an 237499, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaIn this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete <i>Amycolatopsis</i> sp. WP1, yielded six novel amycolachromones A–F (<b>1</b>–<b>6</b>), together with five known analogues (<b>7</b>–<b>11</b>). Amycolachromones A–B (<b>1</b>–<b>2</b>) possessed unique dimer skeletons. The structures and relative configurations of compounds <b>1</b>–<b>11</b> were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A–F were also proposed.https://www.mdpi.com/1660-3397/20/3/162marine actinomycetessecondary metabolitesisolation |
| spellingShingle | Jianwei Chen Jun Chen Siqi Wang Xiaoze Bao Songwei Li Bin Wei Huawei Zhang Hong Wang Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 Marine Drugs marine actinomycetes secondary metabolites isolation |
| title | Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 |
| title_full | Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 |
| title_fullStr | Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 |
| title_full_unstemmed | Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 |
| title_short | Amycolachromones A–F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete <i>Amycolatopsis</i> sp. WP1 |
| title_sort | amycolachromones a f isolated from a streptomycin resistant strain of the deep sea marine actinomycete i amycolatopsis i sp wp1 |
| topic | marine actinomycetes secondary metabolites isolation |
| url | https://www.mdpi.com/1660-3397/20/3/162 |
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