Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study’s aim was to identify the mechanisms involved in tramadol-induced sei...

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Bibliographic Details
Main Authors: Camille Lagard, Dominique Vodovar, Lucie Chevillard, Jacques Callebert, Fabien Caillé, Géraldine Pottier, Hao Liang, Patricia Risède, Nicolas Tournier, Bruno Mégarbane
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
GABA
overdose
positron emission tomography
seizure
tramadol
Online Access:https://www.mdpi.com/1424-8247/15/10/1254

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