A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China
<p>Abstract</p> <p>Background</p> <p>Bronchofiberscopy, a widely used procedure for the diagnosis of various pulmonary diseases within intensive care units, has a history of association with nosocomial infections. Between September and November 2009, an outbreak caused...
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BMC
2012-12-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://www.biomedcentral.com/1471-2334/12/335 |
| _version_ | 1811266931129319424 |
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| author | Xia Yukun Lu CuiLing Zhao Jingya Han Gaige Chen Yong Wang Fang Yi Bin Jiang Guoqin Hu Xiaohua Du Xianfeng Wang Zheng Lei Hong Han Xuelin Han Li |
| author_facet | Xia Yukun Lu CuiLing Zhao Jingya Han Gaige Chen Yong Wang Fang Yi Bin Jiang Guoqin Hu Xiaohua Du Xianfeng Wang Zheng Lei Hong Han Xuelin Han Li |
| author_sort | Xia Yukun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Bronchofiberscopy, a widely used procedure for the diagnosis of various pulmonary diseases within intensive care units, has a history of association with nosocomial infections. Between September and November 2009, an outbreak caused by multidrug-resistant <it>Acinetobacter baumannii</it> (MDR-Ab) was observed in the intensive care unit of a tertiary care hospital in Beijing, China. This study is aimed to describe the course and control of this outbreak and investigate the related risk factors.</p> <p>Methods</p> <p>Clinical and environmental sampling, genotyping with repetitive extragenic palindromic polymerase chain reaction (REP-PCR), and case–control risk factor analysis were performed in the current study.</p> <p>Results</p> <p>During the epidemic period, 12 patients were infected or colonized with MDR-Ab. Sixteen (72.7%) of twenty-two MDR-Ab isolates from the 12 patients and 22 (84.6%) of 26 MDR-Ab isolates from the bronchofiberscope and the healthcare-associated environment were clustered significantly into a major clone (outbreak MDR-Ab strain) by REP-PCR typing. Seven patients carrying the outbreak MDR-Ab strain were defined as the cases. Six of the seven cases (83%) received bronchofiberscopy versus four of the 19 controls (21%) (odds ratio, 22.5; 95% confidence interval, 2.07–244.84; P = 0.005). Several potential administrative and technical problems existed in bronchofiberscope reprocessing.</p> <p>Conclusions</p> <p>Bronchofiberscopy was associated with this MDR-Ab outbreak. Infection control precautions including appropriate bronchofiberscope reprocessing and environmental decontamination should be strengthened.</p> |
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| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T20:52:11Z |
| publishDate | 2012-12-01 |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-2b2f80aa3a154f70b78fef4c57cf5cf82022-12-22T03:17:05ZengBMCBMC Infectious Diseases1471-23342012-12-0112133510.1186/1471-2334-12-335A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, ChinaXia YukunLu CuiLingZhao JingyaHan GaigeChen YongWang FangYi BinJiang GuoqinHu XiaohuaDu XianfengWang ZhengLei HongHan XuelinHan Li<p>Abstract</p> <p>Background</p> <p>Bronchofiberscopy, a widely used procedure for the diagnosis of various pulmonary diseases within intensive care units, has a history of association with nosocomial infections. Between September and November 2009, an outbreak caused by multidrug-resistant <it>Acinetobacter baumannii</it> (MDR-Ab) was observed in the intensive care unit of a tertiary care hospital in Beijing, China. This study is aimed to describe the course and control of this outbreak and investigate the related risk factors.</p> <p>Methods</p> <p>Clinical and environmental sampling, genotyping with repetitive extragenic palindromic polymerase chain reaction (REP-PCR), and case–control risk factor analysis were performed in the current study.</p> <p>Results</p> <p>During the epidemic period, 12 patients were infected or colonized with MDR-Ab. Sixteen (72.7%) of twenty-two MDR-Ab isolates from the 12 patients and 22 (84.6%) of 26 MDR-Ab isolates from the bronchofiberscope and the healthcare-associated environment were clustered significantly into a major clone (outbreak MDR-Ab strain) by REP-PCR typing. Seven patients carrying the outbreak MDR-Ab strain were defined as the cases. Six of the seven cases (83%) received bronchofiberscopy versus four of the 19 controls (21%) (odds ratio, 22.5; 95% confidence interval, 2.07–244.84; P = 0.005). Several potential administrative and technical problems existed in bronchofiberscope reprocessing.</p> <p>Conclusions</p> <p>Bronchofiberscopy was associated with this MDR-Ab outbreak. Infection control precautions including appropriate bronchofiberscope reprocessing and environmental decontamination should be strengthened.</p>http://www.biomedcentral.com/1471-2334/12/335OutbreakBronchofiberscopyMultidrug-resistant <it>Acinetobacter baumannii</it> |
| spellingShingle | Xia Yukun Lu CuiLing Zhao Jingya Han Gaige Chen Yong Wang Fang Yi Bin Jiang Guoqin Hu Xiaohua Du Xianfeng Wang Zheng Lei Hong Han Xuelin Han Li A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China BMC Infectious Diseases Outbreak Bronchofiberscopy Multidrug-resistant <it>Acinetobacter baumannii</it> |
| title | A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China |
| title_full | A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China |
| title_fullStr | A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China |
| title_full_unstemmed | A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China |
| title_short | A bronchofiberoscopy-associated outbreak of multidrug-resistant <it>Acinetobacter baumannii</it> in an intensive care unit in Beijing, China |
| title_sort | bronchofiberoscopy associated outbreak of multidrug resistant it acinetobacter baumannii it in an intensive care unit in beijing china |
| topic | Outbreak Bronchofiberscopy Multidrug-resistant <it>Acinetobacter baumannii</it> |
| url | http://www.biomedcentral.com/1471-2334/12/335 |
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