Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection
Abstract Background The infection rate of human papillomavirus (HPV) is high in the coastal regions of China. However, the infection rate among high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Pu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-022-07893-3 |
| _version_ | 1811207846471139328 |
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| author | Zhanfei Chen Hua Lin Jinyuan Zheng Lili Cai Zhonghui Chen Jinqiu Li Liumin Yu |
| author_facet | Zhanfei Chen Hua Lin Jinyuan Zheng Lili Cai Zhonghui Chen Jinqiu Li Liumin Yu |
| author_sort | Zhanfei Chen |
| collection | DOAJ |
| description | Abstract Background The infection rate of human papillomavirus (HPV) is high in the coastal regions of China. However, the infection rate among high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Putian and provide a reference for the diagnosis, treatment and vaccination of cervical cancer in this region. Methods The data used were obtained from the Chinese government’s public health program (“Cervical and Breast Cancer Screening Project”). A total of 40,693 female cervical cell exfoliation samples screened for high-risk HPV at the Affiliated Hospital of Putian University from July 2020 to December 2021 were enrolled. DNA was extracted using a fully automatic extractor. Then, 14 high-risk genotypes of HPV were detected by polymerase chain reaction. The characteristics of HPV infection, distribution of high-risk genotypes, infection types and thinprep cytologic test (TCT) classification at different age groups were analysed. Results Among the 40,693 samples, 3899 were infected with HPV, with an infection rate of 9.6%. Accordingly, HPV infection rates gradually increased with age, and statistically significant differences were observed among age groups (χ 2 = 74.03, P < 0.01). The infection rates of high-risk HPV52, HPV58 and HPV16 were in the top three and increased with age. Single infection was dominant (84.7%), followed by double infections (12.7%). The cervical cytology of 3899 HPV-positive people can be classified into negative for intraepithelial lesion and malignancy (NILM, 88.0%), atypical squamous cells of undetermined significance (ASC-US, 6.6%), atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion (ASC-H, 1.4%), low-grade squamous intraepithelial lesion (LSIL, 3.2%) and high-grade squamous intraepithelial lesion (HSIL, 0.8%). HPV16 infection rate increased with increasing severity of cervical cytology (χ 2 trend = 43.64, P < 0.01), whereas the infection rates of HPV52 (χ 2 trend = 13.89, P < 0.01) and HPV58 (χ 2 trend = 13.50, P < 0.01) showed opposite trends. Conclusion The infection rate of female HPV high-risk screening in this region was 9.6% and mainly involved single infections. In addition, HPV16, HPV52 and HPV58 were closely related to the severity of cervical cytology. Effective screening, vaccination and education are needed. The 9-valent vaccine will be effective in reducing cervical pre-invasive disease. It would also be reasonable to state that the rising trend in HPV infection and high grade cytology with age emphasises the need to target older women with screening. Vaccination of younger women (aged ≤ 25) will lay the foundation for better cancer outcomes in the future. |
| first_indexed | 2024-04-12T04:11:44Z |
| format | Article |
| id | doaj.art-2b321e5ca77f43ad95ff36d8aad32edb |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T04:11:44Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj.art-2b321e5ca77f43ad95ff36d8aad32edb2022-12-22T03:48:29ZengBMCBMC Infectious Diseases1471-23342022-11-012211910.1186/s12879-022-07893-3Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infectionZhanfei Chen0Hua Lin1Jinyuan Zheng2Lili Cai3Zhonghui Chen4Jinqiu Li5Liumin Yu6The Affiliated Hospital of Putian University, Putian UniversityThe Affiliated Hospital of Putian University, Putian UniversityThe Affiliated Hospital of Putian University, Putian UniversityCenter Blood StationThe Affiliated Hospital of Putian University, Putian UniversityThe Affiliated Hospital of Putian University, Putian UniversityThe Affiliated Hospital of Putian University, Putian UniversityAbstract Background The infection rate of human papillomavirus (HPV) is high in the coastal regions of China. However, the infection rate among high-risk genotypes of women in Putian City is unknown. Therefore, this study aimed to analyse the epidemiology of high-risk HPV infection among women in Putian and provide a reference for the diagnosis, treatment and vaccination of cervical cancer in this region. Methods The data used were obtained from the Chinese government’s public health program (“Cervical and Breast Cancer Screening Project”). A total of 40,693 female cervical cell exfoliation samples screened for high-risk HPV at the Affiliated Hospital of Putian University from July 2020 to December 2021 were enrolled. DNA was extracted using a fully automatic extractor. Then, 14 high-risk genotypes of HPV were detected by polymerase chain reaction. The characteristics of HPV infection, distribution of high-risk genotypes, infection types and thinprep cytologic test (TCT) classification at different age groups were analysed. Results Among the 40,693 samples, 3899 were infected with HPV, with an infection rate of 9.6%. Accordingly, HPV infection rates gradually increased with age, and statistically significant differences were observed among age groups (χ 2 = 74.03, P < 0.01). The infection rates of high-risk HPV52, HPV58 and HPV16 were in the top three and increased with age. Single infection was dominant (84.7%), followed by double infections (12.7%). The cervical cytology of 3899 HPV-positive people can be classified into negative for intraepithelial lesion and malignancy (NILM, 88.0%), atypical squamous cells of undetermined significance (ASC-US, 6.6%), atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion (ASC-H, 1.4%), low-grade squamous intraepithelial lesion (LSIL, 3.2%) and high-grade squamous intraepithelial lesion (HSIL, 0.8%). HPV16 infection rate increased with increasing severity of cervical cytology (χ 2 trend = 43.64, P < 0.01), whereas the infection rates of HPV52 (χ 2 trend = 13.89, P < 0.01) and HPV58 (χ 2 trend = 13.50, P < 0.01) showed opposite trends. Conclusion The infection rate of female HPV high-risk screening in this region was 9.6% and mainly involved single infections. In addition, HPV16, HPV52 and HPV58 were closely related to the severity of cervical cytology. Effective screening, vaccination and education are needed. The 9-valent vaccine will be effective in reducing cervical pre-invasive disease. It would also be reasonable to state that the rising trend in HPV infection and high grade cytology with age emphasises the need to target older women with screening. Vaccination of younger women (aged ≤ 25) will lay the foundation for better cancer outcomes in the future.https://doi.org/10.1186/s12879-022-07893-3Putian City, Fujian ProvinceHuman papillomavirusHigh-risk genotypesEpidemiologyVaccine |
| spellingShingle | Zhanfei Chen Hua Lin Jinyuan Zheng Lili Cai Zhonghui Chen Jinqiu Li Liumin Yu Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection BMC Infectious Diseases Putian City, Fujian Province Human papillomavirus High-risk genotypes Epidemiology Vaccine |
| title | Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection |
| title_full | Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection |
| title_fullStr | Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection |
| title_full_unstemmed | Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection |
| title_short | Epidemiological study of HPV infection in 40,693 women in Putian: a population study based on screening for high-risk HPV infection |
| title_sort | epidemiological study of hpv infection in 40 693 women in putian a population study based on screening for high risk hpv infection |
| topic | Putian City, Fujian Province Human papillomavirus High-risk genotypes Epidemiology Vaccine |
| url | https://doi.org/10.1186/s12879-022-07893-3 |
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