G protein-coupled receptors: the evolution of structural insight

G protein-coupled receptors: the evolution of structural insight

G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins that have gained relevance as biological targets for pharmaceutical drug design. Although these receptors have been investigated for decades, three-dimensional structures of GPCR have only recently become availabl...

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Bibliographic Details
Main Authors:	Samantha B. Gacasan, Daniel L. Baker, Abby L. Parrill
Format:	Article
Language:	English
Published:	AIMS Press 2017-08-01
Series:	AIMS Biophysics
Subjects:	G protein-coupled receptors fusion proteins x-ray crystallography ligand binding agonists antagonists inverse agonists allosteric modulators extracellular loops intracellular loops 7TM domain
Online Access:	http://www.aimspress.com/biophysics/article/1574/fulltext.html

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