The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese
Abstract Left ventricular hypertrophy (LVH) is the most common target organs damage in the hypertension patients. Abnormal low (≤0.9) or high (≥1.40) ankle brachial index (ABI) are associated with an increased risk of cardiovascular events. However, the relationships between a high ABI in the normal...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14328 |
| _version_ | 1797645146818347008 |
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| author | Jin Sun Shuxia Wang Man Li Yongkang Su Shouyuan Ma Yan Zhang Anhang Zhang Shuang Cai Bokai Cheng Qiligeer Bao Ping Zhu |
| author_facet | Jin Sun Shuxia Wang Man Li Yongkang Su Shouyuan Ma Yan Zhang Anhang Zhang Shuang Cai Bokai Cheng Qiligeer Bao Ping Zhu |
| author_sort | Jin Sun |
| collection | DOAJ |
| description | Abstract Left ventricular hypertrophy (LVH) is the most common target organs damage in the hypertension patients. Abnormal low (≤0.9) or high (≥1.40) ankle brachial index (ABI) are associated with an increased risk of cardiovascular events. However, the relationships between a high ABI in the normal range (0.9–1.4) and LVH in Han Chinese hypertension are not entirely elucidated. This study included 3953 hypertension patients aged 40–75 years among Han Chinese. Hypertension was defined as systolic blood pressure≥140 mm Hg, diastolic blood pressure≥90 mm Hg, or history of antihypertensive drug use. Left ventricular mass (LVM) was measured by transthoracic echocardiography. LVH was diagnosed by using the criteria of LVM ≥49.2 g/m2.7 for men and 46.7 g/m2.7 for women. Our study suggested that the ABI was higher in patients with LVH than in those without (1.13±0.11, 1.11±0.11, p < 0.001). The prevalence of LVH in patients with the lowest (0.9 < ABI≤1.03), second (1.04≤ABI≤1.11), the third (1.12≤ABI≤1.20), and the highest quartile (1.21≤ABI < 1.40) of ABI was 37.2%, 38.2%, 45.5%, 45.7%, respectively. Logistic regression analysis suggested that the highest and third quartile of ABI were significantly associated with increased LVH risk (multivariate‐adjusted OR of highest group:1.83; third group:1.61). The association of ABI at second quartile with LVH was nonsignificant. Similar results were observed in less than 60 years and without coronary heart disease or diabetes group. Our observations in Chinese patients with hypertension indicated high ABI may be an important risk factor for LVH in hypertension patients among Han Chinese, even in the normal range. |
| first_indexed | 2024-03-11T14:41:54Z |
| format | Article |
| id | doaj.art-2b34318960ea4a989c31ba5ca5929a5d |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:41:54Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-2b34318960ea4a989c31ba5ca5929a5d2023-10-30T13:30:47ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-09-012391758176610.1111/jch.14328The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han ChineseJin Sun0Shuxia Wang1Man Li2Yongkang Su3Shouyuan Ma4Yan Zhang5Anhang Zhang6Shuang Cai7Bokai Cheng8Qiligeer Bao9Ping Zhu10Medical School of Chinese PLA Beijing ChinaDepartment of Geriatrics The second Medical Center & National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital Beijing ChinaMedical School of Chinese PLA Beijing ChinaMedical School of Chinese PLA Beijing ChinaDepartment of Geriatric Cardiology The second Medical Center, Chinese PLA General Hospital Beijing ChinaDepartment of Outpatient The first Medical Center, Chinese PLA General Hospital Beijing ChinaMedical School of Chinese PLA Beijing ChinaMedical School of Chinese PLA Beijing ChinaMedical School of Chinese PLA Beijing ChinaMedical School of Chinese PLA Beijing ChinaDepartment of Geriatrics The second Medical Center & National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital Beijing ChinaAbstract Left ventricular hypertrophy (LVH) is the most common target organs damage in the hypertension patients. Abnormal low (≤0.9) or high (≥1.40) ankle brachial index (ABI) are associated with an increased risk of cardiovascular events. However, the relationships between a high ABI in the normal range (0.9–1.4) and LVH in Han Chinese hypertension are not entirely elucidated. This study included 3953 hypertension patients aged 40–75 years among Han Chinese. Hypertension was defined as systolic blood pressure≥140 mm Hg, diastolic blood pressure≥90 mm Hg, or history of antihypertensive drug use. Left ventricular mass (LVM) was measured by transthoracic echocardiography. LVH was diagnosed by using the criteria of LVM ≥49.2 g/m2.7 for men and 46.7 g/m2.7 for women. Our study suggested that the ABI was higher in patients with LVH than in those without (1.13±0.11, 1.11±0.11, p < 0.001). The prevalence of LVH in patients with the lowest (0.9 < ABI≤1.03), second (1.04≤ABI≤1.11), the third (1.12≤ABI≤1.20), and the highest quartile (1.21≤ABI < 1.40) of ABI was 37.2%, 38.2%, 45.5%, 45.7%, respectively. Logistic regression analysis suggested that the highest and third quartile of ABI were significantly associated with increased LVH risk (multivariate‐adjusted OR of highest group:1.83; third group:1.61). The association of ABI at second quartile with LVH was nonsignificant. Similar results were observed in less than 60 years and without coronary heart disease or diabetes group. Our observations in Chinese patients with hypertension indicated high ABI may be an important risk factor for LVH in hypertension patients among Han Chinese, even in the normal range.https://doi.org/10.1111/jch.14328ankle brachial indexechocardiographyhypertensionleft ventricular hypertrophy |
| spellingShingle | Jin Sun Shuxia Wang Man Li Yongkang Su Shouyuan Ma Yan Zhang Anhang Zhang Shuang Cai Bokai Cheng Qiligeer Bao Ping Zhu The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese The Journal of Clinical Hypertension ankle brachial index echocardiography hypertension left ventricular hypertrophy |
| title | The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese |
| title_full | The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese |
| title_fullStr | The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese |
| title_full_unstemmed | The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese |
| title_short | The high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the Han Chinese |
| title_sort | high normal ankle brachial index is associated with left ventricular hypertrophy in hypertension patients among the han chinese |
| topic | ankle brachial index echocardiography hypertension left ventricular hypertrophy |
| url | https://doi.org/10.1111/jch.14328 |
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