Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin
The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and...
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| Format: | Article |
| Language: | English |
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Universitas Sanata Dharma
2022-05-01
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| Series: | Jurnal Farmasi Sains dan Komunitas |
| Subjects: | |
| Online Access: | https://e-journal.usd.ac.id/index.php/JFSK/article/view/2183 |
| _version_ | 1827906576360407040 |
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| author | Hadi Barru Hakam Fajar Siddiq Dewi Rashati Siti Nur Azizah |
| author_facet | Hadi Barru Hakam Fajar Siddiq Dewi Rashati Siti Nur Azizah |
| author_sort | Hadi Barru Hakam Fajar Siddiq |
| collection | DOAJ |
| description | The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition. |
| first_indexed | 2024-03-13T00:58:49Z |
| format | Article |
| id | doaj.art-2b34f53faefb44c8815b75eeb635f851 |
| institution | Directory Open Access Journal |
| issn | 1693-5683 2527-7146 |
| language | English |
| last_indexed | 2024-03-13T00:58:49Z |
| publishDate | 2022-05-01 |
| publisher | Universitas Sanata Dharma |
| record_format | Article |
| series | Jurnal Farmasi Sains dan Komunitas |
| spelling | doaj.art-2b34f53faefb44c8815b75eeb635f8512023-07-06T14:02:55ZengUniversitas Sanata DharmaJurnal Farmasi Sains dan Komunitas1693-56832527-71462022-05-01191293310.24071/jpsc.0021832347Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl AmoxicillinHadi Barru Hakam Fajar Siddiq0Dewi Rashati1Siti Nur Azizah2Department of Pharmacy, Akademi Farmasi Jember, Jember, IndonesiaDepartment of Pharmacy, Akademi Farmasi Jember, Jember, IndonesiaDepartment of Pharmacy, Akademi Farmasi Jember, Jember, IndonesiaThe synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition.https://e-journal.usd.ac.id/index.php/JFSK/article/view/21834-tert-butylbenzoyl amoxicillinbacillus subtilisescherichia colispectrometrystaphylococcus aureus |
| spellingShingle | Hadi Barru Hakam Fajar Siddiq Dewi Rashati Siti Nur Azizah Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin Jurnal Farmasi Sains dan Komunitas 4-tert-butylbenzoyl amoxicillin bacillus subtilis escherichia coli spectrometry staphylococcus aureus |
| title | Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin |
| title_full | Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin |
| title_fullStr | Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin |
| title_full_unstemmed | Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin |
| title_short | Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin |
| title_sort | characterization of 1h nmr and 13c nmr spectrometry and antibacterial activities of 4 tert butylbenzoyl amoxicillin |
| topic | 4-tert-butylbenzoyl amoxicillin bacillus subtilis escherichia coli spectrometry staphylococcus aureus |
| url | https://e-journal.usd.ac.id/index.php/JFSK/article/view/2183 |
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