Melatonin and its neuroimmunological actions
Introduction: Melatonin is a neurohormone, synthesized mainly in the pineal gland, which regulates the circadian rhythm. Objective: To describe the neuroimmunological actions produced by melatonin. Materials and methods: A review on the subject was carried out using articles of free access in the Pu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
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Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED)
2020-01-01
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| Series: | Revista Cubana de Investigaciones Biomédicas |
| Subjects: | |
| Online Access: | http://www.revibiomedica.sld.cu/index.php/ibi/article/view/536 |
| _version_ | 1818975169411022848 |
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| author | Jorge Ramón Blanco-Carmona William Quintero-Pérez Alexander Ariel Padrón-González Maricarmen González-Costa Meralys Iglesias del Valle |
| author_facet | Jorge Ramón Blanco-Carmona William Quintero-Pérez Alexander Ariel Padrón-González Maricarmen González-Costa Meralys Iglesias del Valle |
| author_sort | Jorge Ramón Blanco-Carmona |
| collection | DOAJ |
| description | Introduction: Melatonin is a neurohormone, synthesized mainly in the pineal gland, which regulates the circadian rhythm. Objective: To describe the neuroimmunological actions produced by melatonin. Materials and methods: A review on the subject was carried out using articles of free access in the Pubmed database from 2015 to January 2019. Results: The effects of melatonin on the wake-sleep cycle are known. Recently it has been shown that this neurohormone can modulate the immune response and reduce seizures in autoimmune and rheumatologic diseases. It induces the pattern of regulatory T lymphocytes and immunomodulatory cytokines maintaining the homeostasis of the internal environment. In the Central Nervous System inhibits the formation of free radicals, has antioxidant functions and can slow neurodegenerative processes. In the peripheral nerves decreases oxidative stress and cellular apoptosis. There are drugs that use melatonin as an active ingredient for its beneficial effects. In Cuba, only the history of a publication on this hormone is collected. Conclusions: Melatonin can be a very useful element in the management of inflammatory and neurological diseases. |
| first_indexed | 2024-12-20T15:51:41Z |
| format | Article |
| id | doaj.art-2b35e31104f34c1da65a2907e6f9ee57 |
| institution | Directory Open Access Journal |
| issn | 0864-0300 1561-3011 |
| language | Spanish |
| last_indexed | 2024-12-20T15:51:41Z |
| publishDate | 2020-01-01 |
| publisher | Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED) |
| record_format | Article |
| series | Revista Cubana de Investigaciones Biomédicas |
| spelling | doaj.art-2b35e31104f34c1da65a2907e6f9ee572022-12-21T19:34:38ZspaCentro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED)Revista Cubana de Investigaciones Biomédicas0864-03001561-30112020-01-01385344Melatonin and its neuroimmunological actionsJorge Ramón Blanco-Carmona0William Quintero-Pérez1Alexander Ariel Padrón-González2Maricarmen González-Costa3Meralys Iglesias del Valle4Pepe Portilla Provincial Pediatric Hospital. Pinar del RíoPepe Portilla Provincial Pediatric Hospital. Pinar del RíoInstitute of Basic and Preclinical Sciences "Victoria de Girón". University of Medical Sciences of HavanaInstitute of Basic and Preclinical Sciences "Victoria de Girón". University of Medical Sciences of HavanaPepe Portilla Provincial Pediatric Hospital. Pinar del RíoIntroduction: Melatonin is a neurohormone, synthesized mainly in the pineal gland, which regulates the circadian rhythm. Objective: To describe the neuroimmunological actions produced by melatonin. Materials and methods: A review on the subject was carried out using articles of free access in the Pubmed database from 2015 to January 2019. Results: The effects of melatonin on the wake-sleep cycle are known. Recently it has been shown that this neurohormone can modulate the immune response and reduce seizures in autoimmune and rheumatologic diseases. It induces the pattern of regulatory T lymphocytes and immunomodulatory cytokines maintaining the homeostasis of the internal environment. In the Central Nervous System inhibits the formation of free radicals, has antioxidant functions and can slow neurodegenerative processes. In the peripheral nerves decreases oxidative stress and cellular apoptosis. There are drugs that use melatonin as an active ingredient for its beneficial effects. In Cuba, only the history of a publication on this hormone is collected. Conclusions: Melatonin can be a very useful element in the management of inflammatory and neurological diseases.http://www.revibiomedica.sld.cu/index.php/ibi/article/view/536melatonin, inflammation, neurological diseases, immunological diseases |
| spellingShingle | Jorge Ramón Blanco-Carmona William Quintero-Pérez Alexander Ariel Padrón-González Maricarmen González-Costa Meralys Iglesias del Valle Melatonin and its neuroimmunological actions Revista Cubana de Investigaciones Biomédicas melatonin, inflammation, neurological diseases, immunological diseases |
| title | Melatonin and its neuroimmunological actions |
| title_full | Melatonin and its neuroimmunological actions |
| title_fullStr | Melatonin and its neuroimmunological actions |
| title_full_unstemmed | Melatonin and its neuroimmunological actions |
| title_short | Melatonin and its neuroimmunological actions |
| title_sort | melatonin and its neuroimmunological actions |
| topic | melatonin, inflammation, neurological diseases, immunological diseases |
| url | http://www.revibiomedica.sld.cu/index.php/ibi/article/view/536 |
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