Hyaluronan Inhibits Akt, Leading to Nuclear Factor-κB Down-Regulation in Lipopolysaccharide-Stimulated U937 Macrophages

Hyaluronan Inhibits Akt, Leading to Nuclear Factor-κB Down-Regulation in Lipopolysaccharide-Stimulated U937 Macrophages

Hyaluronan (HA) of high molecular weight is used in the treatment of osteoarthritis and rheumatoid arthritis by intra-articular injection. While HA has been shown to suppress nuclear factor (NF)-κB activation by proinflammatory cytokines and lipopolysaccharide (LPS), intracellular upstream events th...

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Bibliographic Details
Main Author:	Tadashi Yasuda
Format:	Article
Language:	English
Published:	Elsevier 2011-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319307467

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