Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report
Local chemotherapy with carmustine-impregnated wafers showed safe and effective in the treatment of malignant glioma, with infrequent, though sometime serious, adverse effects.We report a rare case of cerebral vasospasm following glioblastoma removal with carmustine wafers implantation in a 57-years...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Interdisciplinary Neurosurgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214751918300367 |
| _version_ | 1818864277534015488 |
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| author | Vitaliano F. Muzii Anna Vaiano Sandra Bracco Biagio R. Carangelo |
| author_facet | Vitaliano F. Muzii Anna Vaiano Sandra Bracco Biagio R. Carangelo |
| author_sort | Vitaliano F. Muzii |
| collection | DOAJ |
| description | Local chemotherapy with carmustine-impregnated wafers showed safe and effective in the treatment of malignant glioma, with infrequent, though sometime serious, adverse effects.We report a rare case of cerebral vasospasm following glioblastoma removal with carmustine wafers implantation in a 57-years-old man. After surgery, the patient awoke with aphasia, due to vasospasm of the left middle cerebral artery. Intra-arterial infusion of nimodipine was performed, with rapid vasospasm resolution and quick recovery.Cerebral vasospasm is an extremely rare adverse effect after carmustine wafers implantation in glioma surgery, with only one case reported. In our case, intra-arterial nimodipine was rapidly effective. Although rare, such a potentially disastrous complication should be considered when a new neurological deficit unexpectedly occurs after carmustine wafers implantation, and vascular investigation should be undertaken. Keywords: Cerebral vasospasm, Glioblastoma, Carmustine wafer |
| first_indexed | 2024-12-19T10:29:06Z |
| format | Article |
| id | doaj.art-2b368e6cda0d4060b18f4124e7fb6ec8 |
| institution | Directory Open Access Journal |
| issn | 2214-7519 |
| language | English |
| last_indexed | 2024-12-19T10:29:06Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Interdisciplinary Neurosurgery |
| spelling | doaj.art-2b368e6cda0d4060b18f4124e7fb6ec82022-12-21T20:25:48ZengElsevierInterdisciplinary Neurosurgery2214-75192018-12-01142427Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case reportVitaliano F. Muzii0Anna Vaiano1Sandra Bracco2Biagio R. Carangelo3Department of Medicine, Surgery, and Neurosciences, Section of Neurosurgery, University of Siena, Siena, Italy; Corresponding author at: S. Maria alle Scotte University Hospital, V.le Mario Bracci, 16, 53100 Siena, Italy.Department of Medicine, Surgery, and Neurosciences, Section of Neurosurgery, University of Siena, Siena, ItalyDepartment of Neurological and Sensorineural Sciences, Unit of Neuroimaging and Neurointervention, Azienda Ospedaliera Universitaria Senese, Siena, ItalyDepartment of Neurological and Sensorineural Sciences, Unit of Neurosurgery, Azienda Ospedaliera Universitaria Senese, Siena, ItalyLocal chemotherapy with carmustine-impregnated wafers showed safe and effective in the treatment of malignant glioma, with infrequent, though sometime serious, adverse effects.We report a rare case of cerebral vasospasm following glioblastoma removal with carmustine wafers implantation in a 57-years-old man. After surgery, the patient awoke with aphasia, due to vasospasm of the left middle cerebral artery. Intra-arterial infusion of nimodipine was performed, with rapid vasospasm resolution and quick recovery.Cerebral vasospasm is an extremely rare adverse effect after carmustine wafers implantation in glioma surgery, with only one case reported. In our case, intra-arterial nimodipine was rapidly effective. Although rare, such a potentially disastrous complication should be considered when a new neurological deficit unexpectedly occurs after carmustine wafers implantation, and vascular investigation should be undertaken. Keywords: Cerebral vasospasm, Glioblastoma, Carmustine waferhttp://www.sciencedirect.com/science/article/pii/S2214751918300367 |
| spellingShingle | Vitaliano F. Muzii Anna Vaiano Sandra Bracco Biagio R. Carangelo Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report Interdisciplinary Neurosurgery |
| title | Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report |
| title_full | Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report |
| title_fullStr | Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report |
| title_full_unstemmed | Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report |
| title_short | Symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation. A case report |
| title_sort | symptomatic cerebral vasospasm after glioblastoma resection and carmustine wafers implantation a case report |
| url | http://www.sciencedirect.com/science/article/pii/S2214751918300367 |
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