The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy
Abstract Background We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross‐departmental collaboration to enhance the effectiveness of cancer treatment. Methods We retrospectively evaluated 22 patients with ONB who underwent postoperative radio...
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| Format: | Article |
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Wiley
2024-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6943 |
| _version_ | 1797246018401599488 |
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| author | Yuki Tsutsumi Kazuhiro Omura Yoshikazu Kijima Masao Kobayashi Nei Fukasawa Teppei Takeda Teru Ebihara Satoshi Aoki Nobuyoshi Otori Hiromi Kojima Manabu Aoki |
| author_facet | Yuki Tsutsumi Kazuhiro Omura Yoshikazu Kijima Masao Kobayashi Nei Fukasawa Teppei Takeda Teru Ebihara Satoshi Aoki Nobuyoshi Otori Hiromi Kojima Manabu Aoki |
| author_sort | Yuki Tsutsumi |
| collection | DOAJ |
| description | Abstract Background We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross‐departmental collaboration to enhance the effectiveness of cancer treatment. Methods We retrospectively evaluated 22 patients with ONB who underwent postoperative radiotherapy after tumor resection. En bloc resection was performed; pathology specimens were prepared in coronal sections; and irradiation fields were determined after discussion with radiation oncologists, head and neck surgeons, and pathologists. Results The overall survival and local control rates were 95.5% and 100%, respectively, at a median 37‐month follow‐up. The 3‐ and 5‐year disease‐free survival (DFS) rates were 64.4% and 56.3%, respectively. Of the 22 patients, 9 (8 Kadish C and 1 Kadish B) had disease recurrence. Of the nine patients, five had positive margins and two had closed margins; cervical lymph node recurrence occurred in six, and distant metastasis with or without cervical lymph node recurrence occurred in three. DFS analysis of risk factors showed no statistically significant differences, but positive margins were a significant recurrence factor in multivariate analysis. Conclusions The local control rate of ONB treated with postoperative radiation therapy was 100%. This may be attributed to cross‐departmental cooperation between head and neck surgeons, pathologists, and radiation oncologists, which resulted in accurate matching of CT images for treatment planning with the location of the tumor and positive margins. Longer follow‐up periods are required to evaluate the effectiveness of our strategy. |
| first_indexed | 2024-04-24T19:36:07Z |
| format | Article |
| id | doaj.art-2b397cb5db5346f99233e6e6a91bf8ca |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T19:36:07Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-2b397cb5db5346f99233e6e6a91bf8ca2024-03-25T13:10:38ZengWileyCancer Medicine2045-76342024-03-01135n/an/a10.1002/cam4.6943The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapyYuki Tsutsumi0Kazuhiro Omura1Yoshikazu Kijima2Masao Kobayashi3Nei Fukasawa4Teppei Takeda5Teru Ebihara6Satoshi Aoki7Nobuyoshi Otori8Hiromi Kojima9Manabu Aoki10Department of Radiation Oncology Jikei University School of Medicine Tokyo JapanDepartment of Otorhinolaryngology Jikei University School of Medicine Tokyo JapanDepartment of Radiation Oncology Jikei University School of Medicine Tokyo JapanDepartment of Radiation Oncology Jikei University School of Medicine Tokyo JapanDepartment of Pathology Jikei University School of Medicine Tokyo JapanDepartment of Otorhinolaryngology Jikei University School of Medicine Tokyo JapanDepartment of Otorhinolaryngology Jikei University School of Medicine Tokyo JapanDepartment of Otorhinolaryngology Dokkyo Medical University Saitama Medical Center Saitama JapanDepartment of Otorhinolaryngology Jikei University School of Medicine Tokyo JapanDepartment of Otorhinolaryngology Jikei University School of Medicine Tokyo JapanDepartment of Radiation Oncology Jikei University School of Medicine Tokyo JapanAbstract Background We investigated the outcomes of postoperative radiation therapy for olfactory neuroblastoma (ONB) and our cross‐departmental collaboration to enhance the effectiveness of cancer treatment. Methods We retrospectively evaluated 22 patients with ONB who underwent postoperative radiotherapy after tumor resection. En bloc resection was performed; pathology specimens were prepared in coronal sections; and irradiation fields were determined after discussion with radiation oncologists, head and neck surgeons, and pathologists. Results The overall survival and local control rates were 95.5% and 100%, respectively, at a median 37‐month follow‐up. The 3‐ and 5‐year disease‐free survival (DFS) rates were 64.4% and 56.3%, respectively. Of the 22 patients, 9 (8 Kadish C and 1 Kadish B) had disease recurrence. Of the nine patients, five had positive margins and two had closed margins; cervical lymph node recurrence occurred in six, and distant metastasis with or without cervical lymph node recurrence occurred in three. DFS analysis of risk factors showed no statistically significant differences, but positive margins were a significant recurrence factor in multivariate analysis. Conclusions The local control rate of ONB treated with postoperative radiation therapy was 100%. This may be attributed to cross‐departmental cooperation between head and neck surgeons, pathologists, and radiation oncologists, which resulted in accurate matching of CT images for treatment planning with the location of the tumor and positive margins. Longer follow‐up periods are required to evaluate the effectiveness of our strategy.https://doi.org/10.1002/cam4.6943Hyams gradingKadish stagingmultidisciplinary approacholfactory neuroblastomarecurrencesurvival rates |
| spellingShingle | Yuki Tsutsumi Kazuhiro Omura Yoshikazu Kijima Masao Kobayashi Nei Fukasawa Teppei Takeda Teru Ebihara Satoshi Aoki Nobuyoshi Otori Hiromi Kojima Manabu Aoki The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy Cancer Medicine Hyams grading Kadish staging multidisciplinary approach olfactory neuroblastoma recurrence survival rates |
| title | The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| title_full | The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| title_fullStr | The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| title_full_unstemmed | The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| title_short | The impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| title_sort | impact of multidisciplinary approaches on the outcomes of olfactory neuroblastoma treated with postoperative radiotherapy |
| topic | Hyams grading Kadish staging multidisciplinary approach olfactory neuroblastoma recurrence survival rates |
| url | https://doi.org/10.1002/cam4.6943 |
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