Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcrip...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-09-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1981111 |
| _version_ | 1797677063606370304 |
|---|---|
| author | Joel D. Pearson Rod Bremner |
| author_facet | Joel D. Pearson Rod Bremner |
| author_sort | Joel D. Pearson |
| collection | DOAJ |
| description | The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses. |
| first_indexed | 2024-03-11T22:39:35Z |
| format | Article |
| id | doaj.art-2b3a41e9246742a988601396ee93d929 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:39:35Z |
| publishDate | 2021-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-2b3a41e9246742a988601396ee93d9292023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-09-018510.1080/23723556.2021.19811111981111Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effectsJoel D. Pearson0Rod Bremner1Mt Sinai Hospital, Sinai Health SystemMt Sinai Hospital, Sinai Health SystemThe inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses.http://dx.doi.org/10.1080/23723556.2021.1981111yaptaz/wwtr1neuroendocrine cancersmall cell lung cancerleukemia |
| spellingShingle | Joel D. Pearson Rod Bremner Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects Molecular & Cellular Oncology yap taz/wwtr1 neuroendocrine cancer small cell lung cancer leukemia |
| title | Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects |
| title_full | Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects |
| title_fullStr | Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects |
| title_full_unstemmed | Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects |
| title_short | Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects |
| title_sort | simplifying cancer binary pan cancer superclasses stratified by opposite yap tead effects |
| topic | yap taz/wwtr1 neuroendocrine cancer small cell lung cancer leukemia |
| url | http://dx.doi.org/10.1080/23723556.2021.1981111 |
| work_keys_str_mv | AT joeldpearson simplifyingcancerbinarypancancersuperclassesstratifiedbyoppositeyapteadeffects AT rodbremner simplifyingcancerbinarypancancersuperclassesstratifiedbyoppositeyapteadeffects |