A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke

A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke

We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound <b>1</b>) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico methods, we predicted the phar...

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Bibliographic Details
Main Authors: Denis A. Borozdenko, Aiarpi A. Ezdoglian, Tatiana A. Shmigol, Darya I. Gonchar, Dmitri N. Lyakhmun, Dmitri V. Tarasenko, Yaroslav V. Golubev, Elvira A. Cherkashova, Daria D. Namestnikova, Ilya L. Gubskiy, Alexey A. Lagunin, Leonid V. Gubsky, Vladimir P. Chekhonin, Sophia S. Borisevich, Maxim A. Gureev, Anastasia D. Shagina, Nina M. Kiseleva, Vadim V. Negrebetsky, Yuri I. Baukov
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
synthesis
neuroprotective activity
transient MCAO
experimental ischemic stroke
behavioral tests
Online Access:https://www.mdpi.com/1420-3049/26/20/6124

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