A pan-Zea genome map for enhancing maize improvement

Abstract Background Maize (Zea mays L.) is at the vanguard facing the upcoming breeding challenges. However, both a super pan-genome for the Zea genus and a comprehensive genetic variation map for maize breeding are still lacking. Results Here, we construct an approximately 6.71-Gb pan-Zea genome th...

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Main Authors: Songtao Gui, Wenjie Wei, Chenglin Jiang, Jingyun Luo, Lu Chen, Shenshen Wu, Wenqiang Li, Yuebin Wang, Shuyan Li, Ning Yang, Qing Li, Alisdair R. Fernie, Jianbing Yan
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-022-02742-7
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Summary:Abstract Background Maize (Zea mays L.) is at the vanguard facing the upcoming breeding challenges. However, both a super pan-genome for the Zea genus and a comprehensive genetic variation map for maize breeding are still lacking. Results Here, we construct an approximately 6.71-Gb pan-Zea genome that contains around 4.57-Gb non-B73 reference sequences from fragmented de novo assemblies of 721 pan-Zea individuals. We annotate a total of 58,944 pan-Zea genes and find around 44.34% of them are dispensable in the pan-Zea population. Moreover, 255,821 common structural variations are identified and genotyped in a maize association mapping panel. Further analyses reveal gene presence/absence variants and their potential roles during domestication of maize. Combining genetic analyses with multi-omics data, we demonstrate how structural variants are associated with complex agronomic traits. Conclusions Our results highlight the underexplored role of the pan-Zea genome and structural variations to further understand domestication of maize and explore their potential utilization in crop improvement.
ISSN:1474-760X