Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project
The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 9...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/7/5/75 |
| _version_ | 1797494916170907648 |
|---|---|
| author | Sergey Avdeev Svetlana Rachina Yuliya Belkova Roman Kozlov Ann Versporten Ines Pauwels Herman Goossens Elena Bochanova Elena Elokhina Ulyana Portnjagina Olga Reshetko Igor Sychev Darya Strelkova On behalf of Russian Global-PPS Project Study Group |
| author_facet | Sergey Avdeev Svetlana Rachina Yuliya Belkova Roman Kozlov Ann Versporten Ines Pauwels Herman Goossens Elena Bochanova Elena Elokhina Ulyana Portnjagina Olga Reshetko Igor Sychev Darya Strelkova On behalf of Russian Global-PPS Project Study Group |
| author_sort | Sergey Avdeev |
| collection | DOAJ |
| description | The COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 999 patients in COVID-19 wards in six hospitals surveyed in 2021, 51.3% received antimicrobials (79% in intensive care, 47.5% in medical wards). Systemic antivirals and antibiotics were prescribed to 31% and 35.1% of patients, respectively, and a combination of both to 14.1% of patients. The top antivirals administered were favipiravir (65%), remdesivir (19.2%), and umifenovir (15.8%); the top antibiotics were ceftriaxone (29.7%), levofloxacin (18%), and cefoperazone/sulbactam (10.4%). The vast majority of antibiotics was prescribed for treatment of pneumonia or COVID-19 infection (59.3% and 25.1%, respectively). Treatment was based on biomarker data in 42.7% of patients but was targeted only in 29.6% (6.7% for antibiotics). The rate of non-compliance with guidelines reached 16.6%. Antimicrobial prescribing patterns varied considerably in COVID-19 wards in Russian hospitals with groundlessly high rates of systemic antibiotics. Antimicrobial usage surveillance and stewardship should be applied to inpatient care during the COVID-19 pandemic. |
| first_indexed | 2024-03-10T01:41:06Z |
| format | Article |
| id | doaj.art-2b3b4c40fe514ad286a8f902ce92905f |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T01:41:06Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-2b3b4c40fe514ad286a8f902ce92905f2023-11-23T13:23:45ZengMDPI AGTropical Medicine and Infectious Disease2414-63662022-05-01757510.3390/tropicalmed7050075Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS ProjectSergey Avdeev0Svetlana Rachina1Yuliya Belkova2Roman Kozlov3Ann Versporten4Ines Pauwels5Herman Goossens6Elena Bochanova7Elena Elokhina8Ulyana Portnjagina9Olga Reshetko10Igor Sychev11Darya Strelkova12On behalf of Russian Global-PPS Project Study GroupFirst Moscow State Medical University, 119435 Moscow, RussiaFirst Moscow State Medical University, 119435 Moscow, RussiaSmolensk State Medical University, 214019 Smolensk, RussiaSmolensk State Medical University, 214019 Smolensk, RussiaVaccine and Infectious Disease Institute, University of Antwerp, 2610 Antwerp, BelgiumVaccine and Infectious Disease Institute, University of Antwerp, 2610 Antwerp, BelgiumVaccine and Infectious Disease Institute, University of Antwerp, 2610 Antwerp, BelgiumKrasnoyarsk State Medical University n.a. Professor V. F. Voyno-Yasenetsky, 660022 Krasnoyarsk, RussiaOmsk Regional Clinical Hospital, 644111 Omsk, RussiaNorth-Eastern Federal University, 677007 Yakutsk, RussiaSaratov State Medical University n.a. V. I. Razumovsky, 410000 Saratov, RussiaCity Clinical Hospital n.a. S.S. Yudin, 117198 Moscow, RussiaFirst Moscow State Medical University, 119435 Moscow, RussiaThe COVID-19 pandemic is a global public health challenge with understudied effects on antimicrobial usage. We aimed to analyze antimicrobial prescribing patterns in COVID-19 patients in Russian multi-field hospitals by means of the Global-PPS Project developed by the University of Antwerp. Out of 999 patients in COVID-19 wards in six hospitals surveyed in 2021, 51.3% received antimicrobials (79% in intensive care, 47.5% in medical wards). Systemic antivirals and antibiotics were prescribed to 31% and 35.1% of patients, respectively, and a combination of both to 14.1% of patients. The top antivirals administered were favipiravir (65%), remdesivir (19.2%), and umifenovir (15.8%); the top antibiotics were ceftriaxone (29.7%), levofloxacin (18%), and cefoperazone/sulbactam (10.4%). The vast majority of antibiotics was prescribed for treatment of pneumonia or COVID-19 infection (59.3% and 25.1%, respectively). Treatment was based on biomarker data in 42.7% of patients but was targeted only in 29.6% (6.7% for antibiotics). The rate of non-compliance with guidelines reached 16.6%. Antimicrobial prescribing patterns varied considerably in COVID-19 wards in Russian hospitals with groundlessly high rates of systemic antibiotics. Antimicrobial usage surveillance and stewardship should be applied to inpatient care during the COVID-19 pandemic.https://www.mdpi.com/2414-6366/7/5/75COVID-19hospitalpoint prevalence surveyantimicrobials |
| spellingShingle | Sergey Avdeev Svetlana Rachina Yuliya Belkova Roman Kozlov Ann Versporten Ines Pauwels Herman Goossens Elena Bochanova Elena Elokhina Ulyana Portnjagina Olga Reshetko Igor Sychev Darya Strelkova On behalf of Russian Global-PPS Project Study Group Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project Tropical Medicine and Infectious Disease COVID-19 hospital point prevalence survey antimicrobials |
| title | Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project |
| title_full | Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project |
| title_fullStr | Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project |
| title_full_unstemmed | Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project |
| title_short | Antimicrobial Prescribing Patterns in Patients with COVID-19 in Russian Multi-Field Hospitals in 2021: Results of the Global-PPS Project |
| title_sort | antimicrobial prescribing patterns in patients with covid 19 in russian multi field hospitals in 2021 results of the global pps project |
| topic | COVID-19 hospital point prevalence survey antimicrobials |
| url | https://www.mdpi.com/2414-6366/7/5/75 |
| work_keys_str_mv | AT sergeyavdeev antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT svetlanarachina antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT yuliyabelkova antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT romankozlov antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT annversporten antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT inespauwels antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT hermangoossens antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT elenabochanova antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT elenaelokhina antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT ulyanaportnjagina antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT olgareshetko antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT igorsychev antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT daryastrelkova antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject AT onbehalfofrussianglobalppsprojectstudygroup antimicrobialprescribingpatternsinpatientswithcovid19inrussianmultifieldhospitalsin2021resultsoftheglobalppsproject |