Nuclear factor erythroid 2-related factor 2 modulates HER4 receptor in ovarian cancer cells to influence their sensitivity to tyrosine kinase inhibitors

Nuclear factor erythroid 2-related factor 2 modulates HER4 receptor in ovarian cancer cells to influence their sensitivity to tyrosine kinase inhibitors

Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell’s response to oxidative and electrophilic stress and is a transcription factor regulating the expression of a collection of anti-oxidative and cytoprotective genes. Human epidermal growth factor receptor 4 (HER4/e...

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Bibliographic Details
Main Authors: Ibrahim H. Kankia, Poornima Paramasivan, Matthew Elcombe, Simon P. Langdon, Yusuf Y. Deeni
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2021-04-01
Series:Exploration of Targeted Anti-tumor Therapy
Subjects:
cancer
ovarian
nuclear factor erythroid 2-related factor 2
her4-receptor
regulation
rexinoid
erlotinib
lapatinib
Online Access:https://www.explorationpub.com/Journals/etat/Article/100240

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