Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study
BackgroundA certain number of myasthenia gravis (MG) patients clinically had type 2 diabetes mellitus (T2DM) prior to MG onset, which suggests that the onset of MG may correlate with the history of T2DM. This study aimed to examine the correlation between MG and T2DM.MethodsIn a single-center, retro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1125842/full |
| _version_ | 1797845523730792448 |
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| author | Yu-Dong Liu Fang Tang Fang Tang Xiao-Li Li Xiao-Li Li Ya-Fei Liu Peng Zhang Peng Zhang Chun-Lin Yang Tong Du Heng Li Heng Li Cong-Cong Wang Cong-Cong Wang Ying Liu Bing Yang Bing Yang Rui-Sheng Duan Rui-Sheng Duan |
| author_facet | Yu-Dong Liu Fang Tang Fang Tang Xiao-Li Li Xiao-Li Li Ya-Fei Liu Peng Zhang Peng Zhang Chun-Lin Yang Tong Du Heng Li Heng Li Cong-Cong Wang Cong-Cong Wang Ying Liu Bing Yang Bing Yang Rui-Sheng Duan Rui-Sheng Duan |
| author_sort | Yu-Dong Liu |
| collection | DOAJ |
| description | BackgroundA certain number of myasthenia gravis (MG) patients clinically had type 2 diabetes mellitus (T2DM) prior to MG onset, which suggests that the onset of MG may correlate with the history of T2DM. This study aimed to examine the correlation between MG and T2DM.MethodsIn a single-center, retrospective, 1:5 matched case–control study, all 118 hospitalized patients with a diagnosis of MG from 8 August 2014 to 22 January 2019 were enrolled. In total, four datasets with different sources of the control group were retrieved from the electronic medical records (EMRs). Data were collected at the individual level. A conditional logistic regression analysis was used to test the risk of MG associated with T2DM.FindingsThe risk of MG was significantly associated with T2DM, and there were notable differences by sex and age. Whether compared to the general population, general hospitalized patients without autoimmune diseases (AIDs), or patients with other AIDs except MG, women aged over 50 years with T2DM had an increased risk of MG. The mean onset age of diabetic MG patients was more than that of the non-diabetic MG patients.InterpretationThis study demonstrates that T2DM is strongly associated with the subsequent risk of MG and varies significantly by sex and age. It reveals that diabetic MG may be a unique subtype that is different from the conventional MG subgroup classification. More clinical and immunological features of diabetic MG patients need to be explored in further studies. |
| first_indexed | 2024-04-09T17:40:24Z |
| format | Article |
| id | doaj.art-2b3b977c982b4dbc8cf871dbccb3cf44 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T17:40:24Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2b3b977c982b4dbc8cf871dbccb3cf442023-04-17T05:43:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.11258421125842Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control studyYu-Dong Liu0Fang Tang1Fang Tang2Xiao-Li Li3Xiao-Li Li4Ya-Fei Liu5Peng Zhang6Peng Zhang7Chun-Lin Yang8Tong Du9Heng Li10Heng Li11Cong-Cong Wang12Cong-Cong Wang13Ying Liu14Bing Yang15Bing Yang16Rui-Sheng Duan17Rui-Sheng Duan18Department of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaCenter for Big Data Research in Health and Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaCenter for Big Data Research in Health and Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaShandong Institute of Neuroimmunology, Jinan, ChinaBackgroundA certain number of myasthenia gravis (MG) patients clinically had type 2 diabetes mellitus (T2DM) prior to MG onset, which suggests that the onset of MG may correlate with the history of T2DM. This study aimed to examine the correlation between MG and T2DM.MethodsIn a single-center, retrospective, 1:5 matched case–control study, all 118 hospitalized patients with a diagnosis of MG from 8 August 2014 to 22 January 2019 were enrolled. In total, four datasets with different sources of the control group were retrieved from the electronic medical records (EMRs). Data were collected at the individual level. A conditional logistic regression analysis was used to test the risk of MG associated with T2DM.FindingsThe risk of MG was significantly associated with T2DM, and there were notable differences by sex and age. Whether compared to the general population, general hospitalized patients without autoimmune diseases (AIDs), or patients with other AIDs except MG, women aged over 50 years with T2DM had an increased risk of MG. The mean onset age of diabetic MG patients was more than that of the non-diabetic MG patients.InterpretationThis study demonstrates that T2DM is strongly associated with the subsequent risk of MG and varies significantly by sex and age. It reveals that diabetic MG may be a unique subtype that is different from the conventional MG subgroup classification. More clinical and immunological features of diabetic MG patients need to be explored in further studies.https://www.frontiersin.org/articles/10.3389/fneur.2023.1125842/fullmyasthenia gravistype 2 diabetes mellituscase control studydiabetic myasthenia gravisadvanced glycation end products |
| spellingShingle | Yu-Dong Liu Fang Tang Fang Tang Xiao-Li Li Xiao-Li Li Ya-Fei Liu Peng Zhang Peng Zhang Chun-Lin Yang Tong Du Heng Li Heng Li Cong-Cong Wang Cong-Cong Wang Ying Liu Bing Yang Bing Yang Rui-Sheng Duan Rui-Sheng Duan Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study Frontiers in Neurology myasthenia gravis type 2 diabetes mellitus case control study diabetic myasthenia gravis advanced glycation end products |
| title | Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study |
| title_full | Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study |
| title_fullStr | Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study |
| title_full_unstemmed | Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study |
| title_short | Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case–control study |
| title_sort | type 2 diabetes mellitus as a possible risk factor for myasthenia gravis a case control study |
| topic | myasthenia gravis type 2 diabetes mellitus case control study diabetic myasthenia gravis advanced glycation end products |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1125842/full |
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