Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential
Aging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increased vulnerability to disease as a function of age....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417302505 |
| _version_ | 1818199333879676928 |
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| author | Priya Balasubramanian Porsha R. Howell Rozalyn M. Anderson |
| author_facet | Priya Balasubramanian Porsha R. Howell Rozalyn M. Anderson |
| author_sort | Priya Balasubramanian |
| collection | DOAJ |
| description | Aging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increased vulnerability to disease as a function of age. Aging research as a discipline is necessarily broad; in part because aging itself is multi-faceted and in part because different model systems are employed to define the underlying biology. In this review we outline aspects of aging research that are likely to uncover the pivotal events leading to age-related disease vulnerability. We focus on studies of human aging and discuss the value of research on caloric restriction, an intervention with proven efficacy in delaying aging. We propose that studies such as these will deliver target factors and processes that create vulnerability in human aging, an advance that would potentially be transformative in clinical care. |
| first_indexed | 2024-12-12T02:20:06Z |
| format | Article |
| id | doaj.art-2b3c2700336a420d868c9730664579df |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-12T02:20:06Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-2b3c2700336a420d868c9730664579df2022-12-22T00:41:42ZengElsevierEBioMedicine2352-39642017-07-0121C374410.1016/j.ebiom.2017.06.015Aging and Caloric Restriction Research: A Biological Perspective With Translational PotentialPriya Balasubramanian0Porsha R. Howell1Rozalyn M. Anderson2Department of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin Madison, WI 53792, United StatesDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin Madison, WI 53792, United StatesDepartment of Medicine, Division of Geriatrics and Gerontology, School of Medicine and Public Health, University of Wisconsin Madison, WI 53792, United StatesAging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increased vulnerability to disease as a function of age. Aging research as a discipline is necessarily broad; in part because aging itself is multi-faceted and in part because different model systems are employed to define the underlying biology. In this review we outline aspects of aging research that are likely to uncover the pivotal events leading to age-related disease vulnerability. We focus on studies of human aging and discuss the value of research on caloric restriction, an intervention with proven efficacy in delaying aging. We propose that studies such as these will deliver target factors and processes that create vulnerability in human aging, an advance that would potentially be transformative in clinical care.http://www.sciencedirect.com/science/article/pii/S2352396417302505Caloric restrictionAgingMetabolismHumansNonhuman primates |
| spellingShingle | Priya Balasubramanian Porsha R. Howell Rozalyn M. Anderson Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential EBioMedicine Caloric restriction Aging Metabolism Humans Nonhuman primates |
| title | Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential |
| title_full | Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential |
| title_fullStr | Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential |
| title_full_unstemmed | Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential |
| title_short | Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential |
| title_sort | aging and caloric restriction research a biological perspective with translational potential |
| topic | Caloric restriction Aging Metabolism Humans Nonhuman primates |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417302505 |
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