Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved]
Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-06-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/5-1466/v1 |
| _version_ | 1819014530536046592 |
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| author | James Addington Miriam Freimer |
| author_facet | James Addington Miriam Freimer |
| author_sort | James Addington |
| collection | DOAJ |
| description | Chemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects. |
| first_indexed | 2024-12-21T02:17:18Z |
| format | Article |
| id | doaj.art-2b3ce33a3de44f299803fd0cf37feb7d |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T02:17:18Z |
| publishDate | 2016-06-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-2b3ce33a3de44f299803fd0cf37feb7d2022-12-21T19:19:15ZengF1000 Research LtdF1000Research2046-14022016-06-01510.12688/f1000research.8053.18664Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved]James Addington0Miriam Freimer1Department of Neurology, The Ohio State University, Columbus, OH, USADepartment of Neurology, The Ohio State University, Columbus, OH, USAChemotherapy-induced peripheral neuropathy is a common side effect of selected chemotherapeutic agents. Previous work has suggested that patients often under report the symptoms of chemotherapy-induced peripheral neuropathy and physicians fail to recognize the presence of such symptoms in a timely fashion. The precise pathophysiology that underlies chemotherapy-induced peripheral neuropathy, in both the acute and the chronic phase, remains complex and appears to be medication specific. Recent work has begun to demonstrate and further clarify potential pathophysiological processes that predispose and, ultimately, lead to the development of chemotherapy-induced peripheral neuropathy. There is increasing evidence that the pathway to neuropathy varies with each agent. With a clearer understanding of how these agents affect the peripheral nervous system, more targeted treatments can be developed in order to optimize treatment and prevent long-term side effects.http://f1000research.com/articles/5-1466/v1Cancer TherapeuticsDevelopmental & Pediatric NeurologyMotor SystemsNeurobiology of Disease & RegenerationPeripheral NeuropathiesSensory SystemsToxicology |
| spellingShingle | James Addington Miriam Freimer Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] F1000Research Cancer Therapeutics Developmental & Pediatric Neurology Motor Systems Neurobiology of Disease & Regeneration Peripheral Neuropathies Sensory Systems Toxicology |
| title | Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] |
| title_full | Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] |
| title_fullStr | Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] |
| title_full_unstemmed | Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] |
| title_short | Chemotherapy-induced peripheral neuropathy: an update on the current understanding [version 1; referees: 2 approved] |
| title_sort | chemotherapy induced peripheral neuropathy an update on the current understanding version 1 referees 2 approved |
| topic | Cancer Therapeutics Developmental & Pediatric Neurology Motor Systems Neurobiology of Disease & Regeneration Peripheral Neuropathies Sensory Systems Toxicology |
| url | http://f1000research.com/articles/5-1466/v1 |
| work_keys_str_mv | AT jamesaddington chemotherapyinducedperipheralneuropathyanupdateonthecurrentunderstandingversion1referees2approved AT miriamfreimer chemotherapyinducedperipheralneuropathyanupdateonthecurrentunderstandingversion1referees2approved |