Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males
Abstract Sinusoidal squat‐stand maneuvers (SSM) without resistance have been shown to produce ~30–50 mmHg swings in mean arterial pressure which are largely buffered in the brain via dynamic cerebral autoregulation (dCA). This study aimed to further elucidate how this regulatory mechanism is affecte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-05-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15278 |
| _version_ | 1797387576470929408 |
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| author | Kailey T. Newel Joel S. Burma Joseph Carere Courtney M. Kennedy Jonathan D. Smirl |
| author_facet | Kailey T. Newel Joel S. Burma Joseph Carere Courtney M. Kennedy Jonathan D. Smirl |
| author_sort | Kailey T. Newel |
| collection | DOAJ |
| description | Abstract Sinusoidal squat‐stand maneuvers (SSM) without resistance have been shown to produce ~30–50 mmHg swings in mean arterial pressure which are largely buffered in the brain via dynamic cerebral autoregulation (dCA). This study aimed to further elucidate how this regulatory mechanism is affected during SSM with added resistance (~20% bodyweight). Twenty‐five participants (sex/gender: 13 females/12 males) completed two bouts of 5‐min SSM for both bodyweight and resistance conditions (10% bodyweight in each arm) at frequencies of 0.05 Hz (20‐s squat/stand cycles) and 0.10 Hz (10‐s squat/stand cycles). Middle and posterior cerebral artery (MCA/PCA) cerebral blood velocities were indexed with transcranial Doppler ultrasound. Beat‐to‐beat blood pressure (BP) was quantified via finger photoplesmography. Transfer function analysis was employed to quantify dCA in both cerebral arteries across the cardiac cycle (diastole, mean, and systole). Two‐by‐two Analysis of Variance with generalized eta squared effect sizes were utilized to determine differences between resistance vs. bodyweight squats and between sexes/genders. Absolute mean and diastolic BP were elevated during the resistance squats (p < 0.001); however, only the BP point‐estimate power spectrum densities were augmented at 0.10 Hz (p < 0.048). No differences were noted for phase and gain metrics between bodyweight and resistance SSM (p > 0.067); however, females displayed attenuated systolic regulation (p < 0.003). Despite augmented systemic BP during resistance SSM, the brain was effective at buffering the additional stress to mitigate overperfusion/pressure. Females displayed less dCA regulation within the systolic aspect of the cardiac cycle, which may be associated with physiological underpinnings related to various clinical conditions/presentations. |
| first_indexed | 2024-03-08T22:28:08Z |
| format | Article |
| id | doaj.art-2b3d2e9115154573adcfdb6c7d30fe89 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T22:28:08Z |
| publishDate | 2022-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-2b3d2e9115154573adcfdb6c7d30fe892023-12-18T09:26:14ZengWileyPhysiological Reports2051-817X2022-05-011010n/an/a10.14814/phy2.15278Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and malesKailey T. Newel0Joel S. Burma1Joseph Carere2Courtney M. Kennedy3Jonathan D. Smirl4Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary Alberta CanadaCerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary Alberta CanadaCerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary Alberta CanadaCerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary Alberta CanadaCerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary Alberta CanadaAbstract Sinusoidal squat‐stand maneuvers (SSM) without resistance have been shown to produce ~30–50 mmHg swings in mean arterial pressure which are largely buffered in the brain via dynamic cerebral autoregulation (dCA). This study aimed to further elucidate how this regulatory mechanism is affected during SSM with added resistance (~20% bodyweight). Twenty‐five participants (sex/gender: 13 females/12 males) completed two bouts of 5‐min SSM for both bodyweight and resistance conditions (10% bodyweight in each arm) at frequencies of 0.05 Hz (20‐s squat/stand cycles) and 0.10 Hz (10‐s squat/stand cycles). Middle and posterior cerebral artery (MCA/PCA) cerebral blood velocities were indexed with transcranial Doppler ultrasound. Beat‐to‐beat blood pressure (BP) was quantified via finger photoplesmography. Transfer function analysis was employed to quantify dCA in both cerebral arteries across the cardiac cycle (diastole, mean, and systole). Two‐by‐two Analysis of Variance with generalized eta squared effect sizes were utilized to determine differences between resistance vs. bodyweight squats and between sexes/genders. Absolute mean and diastolic BP were elevated during the resistance squats (p < 0.001); however, only the BP point‐estimate power spectrum densities were augmented at 0.10 Hz (p < 0.048). No differences were noted for phase and gain metrics between bodyweight and resistance SSM (p > 0.067); however, females displayed attenuated systolic regulation (p < 0.003). Despite augmented systemic BP during resistance SSM, the brain was effective at buffering the additional stress to mitigate overperfusion/pressure. Females displayed less dCA regulation within the systolic aspect of the cardiac cycle, which may be associated with physiological underpinnings related to various clinical conditions/presentations.https://doi.org/10.14814/phy2.15278cerebral blood flow regulationdoppler ultrasounddynamic cerebral autoregulationresistance exercisesquat‐stand maneuvers |
| spellingShingle | Kailey T. Newel Joel S. Burma Joseph Carere Courtney M. Kennedy Jonathan D. Smirl Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males Physiological Reports cerebral blood flow regulation doppler ultrasound dynamic cerebral autoregulation resistance exercise squat‐stand maneuvers |
| title | Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males |
| title_full | Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males |
| title_fullStr | Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males |
| title_full_unstemmed | Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males |
| title_short | Does oscillation size matter? Impact of added resistance on the cerebral pressure‐flow Relationship in females and males |
| title_sort | does oscillation size matter impact of added resistance on the cerebral pressure flow relationship in females and males |
| topic | cerebral blood flow regulation doppler ultrasound dynamic cerebral autoregulation resistance exercise squat‐stand maneuvers |
| url | https://doi.org/10.14814/phy2.15278 |
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