Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model

Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model

Abstract The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to tumor recurrence. Understanding cellular interactions in the PVN that drive GSC treatment resistance and ste...

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Bibliographic Details
Main Authors: Emmanuela A. Adjei‐Sowah, Samantha A. O'Connor, Jaimeson Veldhuizen, Costanza Lo Cascio, Christopher Plaisier, Shwetal Mehta, Mehdi Nikkhah
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
glioblastoma
invasion
perivascular niche
transcriptomics
tumor microenvironment
Online Access:https://doi.org/10.1002/advs.202201436

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