Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India
Introduction: Glycated Hemoglobin (HbA1c) levels are predictive of cardiovascular disease and mortality in patients with diabetes mellitus, however, association of HbA1c with Coronary Artery Disease (CAD) in non-diabetics is inconsistent. Aim: To evaluate the correlation between HbA1c level and...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8525/22378_CE[EK_OM]_F(GH)_PF1(SHAK)_PFA(NC_AK)_PF2(PEK).pdf |
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| author | BORNALI DUTTA MAHESH NEGINHAL FARHIN IQBAL |
| author_facet | BORNALI DUTTA MAHESH NEGINHAL FARHIN IQBAL |
| author_sort | BORNALI DUTTA |
| collection | DOAJ |
| description | Introduction: Glycated Hemoglobin (HbA1c) levels are
predictive of cardiovascular disease and mortality in patients
with diabetes mellitus, however, association of HbA1c with
Coronary Artery Disease (CAD) in non-diabetics is inconsistent.
Aim: To evaluate the correlation between HbA1c level and
severity of CAD in non-diabetic patients using syntax score
in a cohort of proven CAD on angiography at Gauhati Medical
College, Guwahati, Assam, India, which is a major tertiary care
hospital of North-Eastern India.
Materials and Methods: We prospectively collected data of
non-diabetic patients with proven CAD on angiography from
June 2014 to June 2015. Patients were divided into four groups
(interquartiles) according to HbA1c levels, less than 4.8%, 4.8%
to 5.1%, 5.1% to 5.6%, and 5.6% to 6.5%. Severity of CAD
was assessed using syntax score and the number of coronary
vessels diseased. We compared different quartiles of HbA1c
with regard to syntax score and number of diseased vessels.
Results: A total of 346 patients were included in the study.
Mean age was 58.1±10.4 years. Of the total 91.9% (318) were
males, 44.8% (155) were hypertensives, 29.2% (101) were
smokers and 34.7% (120) were dyslipidemic. We found that
CAD severity by syntax score as well as number of vessels
involved was significantly different among quartiles (p-values
<0.001 and <0.001 respectively). Increase in HbA1c level was
strongly correlated with disease severity and higher syntax
score. A significant increase was noted in the mean number
of diseased vessels (p-value <0.001) as HbA1c level increases.
Age, gender, hypertension and dyslipidemia did not show
significant difference among quartiles however smoking was
found to be an independent predictor of severity of CAD by
syntax score (p <0.05).
Conclusion: From this clinical study, we can conclude that a
significant correlation exists between HbA1c and severity of
CAD by syntax score as well as number of vessels involved in
non- diabetes. |
| first_indexed | 2024-12-13T11:40:51Z |
| format | Article |
| id | doaj.art-2b3ee823d8f24e5fabe430413af889c2 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T11:40:51Z |
| publishDate | 2016-09-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-2b3ee823d8f24e5fabe430413af889c22022-12-21T23:47:39ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-09-01109OC20OC2310.7860/JCDR/2016/22378.8525Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern IndiaBORNALI DUTTA0MAHESH NEGINHAL1FARHIN IQBAL2Associate Professor, Department of Cardiology, Gauhati Medical College, Guwahati, Assam, India.Senior Resident, Department of Cardiology, Gauhati Medical College, Guwahati, Assam, India.Assistant Professor, Department of Cardiology, Gauhati Medical College, Guwahati, Assam, India.Introduction: Glycated Hemoglobin (HbA1c) levels are predictive of cardiovascular disease and mortality in patients with diabetes mellitus, however, association of HbA1c with Coronary Artery Disease (CAD) in non-diabetics is inconsistent. Aim: To evaluate the correlation between HbA1c level and severity of CAD in non-diabetic patients using syntax score in a cohort of proven CAD on angiography at Gauhati Medical College, Guwahati, Assam, India, which is a major tertiary care hospital of North-Eastern India. Materials and Methods: We prospectively collected data of non-diabetic patients with proven CAD on angiography from June 2014 to June 2015. Patients were divided into four groups (interquartiles) according to HbA1c levels, less than 4.8%, 4.8% to 5.1%, 5.1% to 5.6%, and 5.6% to 6.5%. Severity of CAD was assessed using syntax score and the number of coronary vessels diseased. We compared different quartiles of HbA1c with regard to syntax score and number of diseased vessels. Results: A total of 346 patients were included in the study. Mean age was 58.1±10.4 years. Of the total 91.9% (318) were males, 44.8% (155) were hypertensives, 29.2% (101) were smokers and 34.7% (120) were dyslipidemic. We found that CAD severity by syntax score as well as number of vessels involved was significantly different among quartiles (p-values <0.001 and <0.001 respectively). Increase in HbA1c level was strongly correlated with disease severity and higher syntax score. A significant increase was noted in the mean number of diseased vessels (p-value <0.001) as HbA1c level increases. Age, gender, hypertension and dyslipidemia did not show significant difference among quartiles however smoking was found to be an independent predictor of severity of CAD by syntax score (p <0.05). Conclusion: From this clinical study, we can conclude that a significant correlation exists between HbA1c and severity of CAD by syntax score as well as number of vessels involved in non- diabetes.https://jcdr.net/articles/PDF/8525/22378_CE[EK_OM]_F(GH)_PF1(SHAK)_PFA(NC_AK)_PF2(PEK).pdfcardiovascular riskglycemic controlsyntax score |
| spellingShingle | BORNALI DUTTA MAHESH NEGINHAL FARHIN IQBAL Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India Journal of Clinical and Diagnostic Research cardiovascular risk glycemic control syntax score |
| title | Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India |
| title_full | Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India |
| title_fullStr | Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India |
| title_full_unstemmed | Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India |
| title_short | Glycated Hemoglobin (HbA1c) Correlation with Severity of Coronary Artery Disease in Non-diabetic Patients - A Hospital based Study from North-Eastern India |
| title_sort | glycated hemoglobin hba1c correlation with severity of coronary artery disease in non diabetic patients a hospital based study from north eastern india |
| topic | cardiovascular risk glycemic control syntax score |
| url | https://jcdr.net/articles/PDF/8525/22378_CE[EK_OM]_F(GH)_PF1(SHAK)_PFA(NC_AK)_PF2(PEK).pdf |
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