Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient
Presentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2011-06-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/upload_files/pdf/18932.pdf |
| _version_ | 1818806377457385472 |
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| author | Reza Mollahoseini Mahdi Nikoobakht |
| author_facet | Reza Mollahoseini Mahdi Nikoobakht |
| author_sort | Reza Mollahoseini |
| collection | DOAJ |
| description | Presentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric and dural lesions. An open biopsy was conducted. Histological evaluation revealed hyphe-like structure in the necrotic area, within vessel walls, and lumina, suggestive aspergillus fumigatus . Furthermore, brancheal hyphae in potassium hydrxide15% and colonies on sabourud dextrose agar were observed. Based of the above findings the patient underwent anti fungal therapy. The patient recovered and continued a normal life however a follow up MRI was performed after 3 months from recovery. No significant abnormality was observed from the MRI procedure. One month later the patient developed signs and symptoms of spinal cord involvement which seemed to be the result of myelitis. A brain MR showed no abnormalities .Therefore it seemed reasonable to administer corticosteroid as a treatment for suspected active demyelinating process. During the above treatment, signs and symptoms of myelopathy disappeared and a whole spine MRI showed remarkable improvement. |
| first_indexed | 2024-12-18T19:08:48Z |
| format | Article |
| id | doaj.art-2b40dfba145c42dfbd1f8225ea8bbc1e |
| institution | Directory Open Access Journal |
| issn | 0044-6025 |
| language | English |
| last_indexed | 2024-12-18T19:08:48Z |
| publishDate | 2011-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-2b40dfba145c42dfbd1f8225ea8bbc1e2022-12-21T20:56:19ZengTehran University of Medical SciencesActa Medica Iranica0044-60252011-06-01496402406Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent PatientReza MollahoseiniMahdi NikoobakhtPresentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric and dural lesions. An open biopsy was conducted. Histological evaluation revealed hyphe-like structure in the necrotic area, within vessel walls, and lumina, suggestive aspergillus fumigatus . Furthermore, brancheal hyphae in potassium hydrxide15% and colonies on sabourud dextrose agar were observed. Based of the above findings the patient underwent anti fungal therapy. The patient recovered and continued a normal life however a follow up MRI was performed after 3 months from recovery. No significant abnormality was observed from the MRI procedure. One month later the patient developed signs and symptoms of spinal cord involvement which seemed to be the result of myelitis. A brain MR showed no abnormalities .Therefore it seemed reasonable to administer corticosteroid as a treatment for suspected active demyelinating process. During the above treatment, signs and symptoms of myelopathy disappeared and a whole spine MRI showed remarkable improvement.http://journals.tums.ac.ir/upload_files/pdf/18932.pdfAspergillus fumigatesAspergillosisMyelitis |
| spellingShingle | Reza Mollahoseini Mahdi Nikoobakht Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient Acta Medica Iranica Aspergillus fumigates Aspergillosis Myelitis |
| title | Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient |
| title_full | Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient |
| title_fullStr | Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient |
| title_full_unstemmed | Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient |
| title_short | Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient |
| title_sort | diffuse myelitis after treatment of cerebral aspergillosis in an immune competent patient |
| topic | Aspergillus fumigates Aspergillosis Myelitis |
| url | http://journals.tums.ac.ir/upload_files/pdf/18932.pdf |
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