Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo
Aim:Vertigo is a common presenting complaint to the emergency department (ED). Distinguishing between acute central and peripheral vertigo can be challenging. During recent years, several biomarkers have been introduced for use in distinguishing central and peripheral vertigo. The current study dete...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-12-01
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| Series: | Eurasian Journal of Emergency Medicine |
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http://eajem.com/archives/archive-detail/article-preview/diagnostic-value-of-s100b-and-neuron-specific-enol/57479
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| _version_ | 1797921532857548800 |
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| author | Babak Masoumi Razieh Bagheri Farhad Heydari Abaris Massoumi Behnaz Ansari Mohammad Nasr-Esfahani |
| author_facet | Babak Masoumi Razieh Bagheri Farhad Heydari Abaris Massoumi Behnaz Ansari Mohammad Nasr-Esfahani |
| author_sort | Babak Masoumi |
| collection | DOAJ |
| description | Aim:Vertigo is a common presenting complaint to the emergency department (ED). Distinguishing between acute central and peripheral vertigo can be challenging. During recent years, several biomarkers have been introduced for use in distinguishing central and peripheral vertigo. The current study determined whether S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE) serum concentrations could effectively predict the central causes of vertigo.Materials and Methods:This was a prospective study performed on 117 patients with acute vertigo who were admitted to the ED. All patients underwent magnetic resonance imaging (MRI) and the results of the MRI were considered the gold standard. S100B and NSE from blood samples taken <8 h after the onset of symptoms were measured in all patients.Results:Finally, 117 patients were enrolled in the study, of which 43 patients had central vertigo and 74 patients had peripheral vertigo. The serum levels of S100B and NSE in the central group were significantly higher (60.62 vs 28.01 pg/mL, and 11.86 vs 7 ng/mL, p<0.001, respectively). The receiver-operating characteristic analysis demonstrated an AUC of 0.91 [95% confidence interval (CI): 0.84-0.96] and 0.93 (95% CI: 0.87-0.97) for S100B and NSE for predicting central vertigo and reported a sensitivity of 97.7% and 93% and a specificity of 87.8% and 89.2% for detecting the central cause of vertigo with S100B and NSE.Conclusion:The serum S100B and NSE concentrations in central vertigo were significantly higher, and could be useful markers in screening central from peripheral vertigo in the ED. |
| first_indexed | 2024-04-10T14:17:16Z |
| format | Article |
| id | doaj.art-2b41eca181f44f60bca3dea70e77f4ac |
| institution | Directory Open Access Journal |
| issn | 2149-5807 2149-6048 |
| language | English |
| last_indexed | 2024-04-10T14:17:16Z |
| publishDate | 2022-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Eurasian Journal of Emergency Medicine |
| spelling | doaj.art-2b41eca181f44f60bca3dea70e77f4ac2023-02-15T16:09:28ZengGalenos YayineviEurasian Journal of Emergency Medicine2149-58072149-60482022-12-0121424625110.4274/eajem.galenos.2022.8268713049054Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral VertigoBabak Masoumi0Razieh Bagheri1Farhad Heydari2Abaris Massoumi3Behnaz Ansari4Mohammad Nasr-Esfahani5 Isfahan University of Medical Sciences Faculty of Medicine, Department of Emergency Medicine, Isfahan, Iran Isfahan University of Medical Sciences Faculty of Medicine, Department of Emergency Medicine, Isfahan, Iran Isfahan University of Medical Sciences Faculty of Medicine, Department of Emergency Medicine, Isfahan, Iran London North West University Healthcare NHS Trust, Ealing Hospital, Department of General Surgery, London, UK Isfahan University of Medical Sciences Faculty of Medicine, Department of Neurology, Isfahan, Iran Isfahan University of Medical Sciences Faculty of Medicine, Department of Emergency Medicine, Isfahan, Iran Aim:Vertigo is a common presenting complaint to the emergency department (ED). Distinguishing between acute central and peripheral vertigo can be challenging. During recent years, several biomarkers have been introduced for use in distinguishing central and peripheral vertigo. The current study determined whether S100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE) serum concentrations could effectively predict the central causes of vertigo.Materials and Methods:This was a prospective study performed on 117 patients with acute vertigo who were admitted to the ED. All patients underwent magnetic resonance imaging (MRI) and the results of the MRI were considered the gold standard. S100B and NSE from blood samples taken <8 h after the onset of symptoms were measured in all patients.Results:Finally, 117 patients were enrolled in the study, of which 43 patients had central vertigo and 74 patients had peripheral vertigo. The serum levels of S100B and NSE in the central group were significantly higher (60.62 vs 28.01 pg/mL, and 11.86 vs 7 ng/mL, p<0.001, respectively). The receiver-operating characteristic analysis demonstrated an AUC of 0.91 [95% confidence interval (CI): 0.84-0.96] and 0.93 (95% CI: 0.87-0.97) for S100B and NSE for predicting central vertigo and reported a sensitivity of 97.7% and 93% and a specificity of 87.8% and 89.2% for detecting the central cause of vertigo with S100B and NSE.Conclusion:The serum S100B and NSE concentrations in central vertigo were significantly higher, and could be useful markers in screening central from peripheral vertigo in the ED. http://eajem.com/archives/archive-detail/article-preview/diagnostic-value-of-s100b-and-neuron-specific-enol/57479 neuron-specific enolases100bcentral vertigoperipheral vertigoemergency department |
| spellingShingle | Babak Masoumi Razieh Bagheri Farhad Heydari Abaris Massoumi Behnaz Ansari Mohammad Nasr-Esfahani Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo Eurasian Journal of Emergency Medicine neuron-specific enolase s100b central vertigo peripheral vertigo emergency department |
| title | Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo |
| title_full | Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo |
| title_fullStr | Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo |
| title_full_unstemmed | Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo |
| title_short | Diagnostic Value of S100B and Neuron-specific Enolase in Distinguishing Acute Central and Peripheral Vertigo |
| title_sort | diagnostic value of s100b and neuron specific enolase in distinguishing acute central and peripheral vertigo |
| topic | neuron-specific enolase s100b central vertigo peripheral vertigo emergency department |
| url |
http://eajem.com/archives/archive-detail/article-preview/diagnostic-value-of-s100b-and-neuron-specific-enol/57479
|
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