NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation

NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation

Lipocalin-2 (LCN2), a small secretory glycoprotein, is upregulated by toll-like receptor (TLR) signaling in various cells and tissues. LCN2 inhibits bacterial growth by iron sequestration and regulates the innate immune system. Inflammasome activates the inflammatory caspases leading to pyroptosis a...

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Bibliographic Details
Main Authors: Huijeong Ahn, Gilyoung Lee, Jeongeun Kim, Jeongho Park, Seung Goo Kang, Sung-Il Yoon, Eunsong Lee, Geun-Shik Lee
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
lipocalin-2
NLRP3 inflammasome
nigericin
macrophages
Online Access:https://www.mdpi.com/2073-4409/10/7/1660

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