Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study

Introductions: Recurrent aphthous stomatitis (RAS) is a common disease and suitable treatment has been unsuccessful. The purpose of this study was evaluating oral wound healing process following use of Oralmedic. Methods: In this animal study, mucosal ulcers with the same size were made in the lowe...

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Main Authors: MH Akhavan Karbassi, SH Tabatabai, KH Kheirollahi, H Kheirollahi
Format: Article
Language:fas
Published: Shahid Sadoughi University of Medical Sciences 2016-05-01
Series:Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Subjects:
Online Access:http://jssu.ssu.ac.ir/browse.php?a_code=A-10-2438-1&slc_lang=en&sid=1
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author MH Akhavan Karbassi
SH Tabatabai
KH Kheirollahi
H Kheirollahi
author_facet MH Akhavan Karbassi
SH Tabatabai
KH Kheirollahi
H Kheirollahi
author_sort MH Akhavan Karbassi
collection DOAJ
description Introductions: Recurrent aphthous stomatitis (RAS) is a common disease and suitable treatment has been unsuccessful. The purpose of this study was evaluating oral wound healing process following use of Oralmedic. Methods: In this animal study, mucosal ulcers with the same size were made in the lower lip of 12 mice with the same weight, gender and race. The mice were selected randomly divided into two groups of six mice each, oralmedic and distilled groups. The Oralmedic has been used on the wound in the first group and distilled water was applied on the wound in the second group twice a day for 5 days. On the fifteenth day, biopsy was obtained from wound healing areas and they were investigated through microscopic examination. Results: The epithelium in the restored areas in both two groups was almost normal (p>0.05). In the studied groups, oral medic created different inflammatory effects in the connective tissues. In terms of medicine, formation of the granulation tissue showed a significant difference between two groups, but this difference was not statistically significant. The amount of collagen in the connective tissues were different. Histologic observations showed that after using Oralmedic, some changes such as inflammation, scar formation, and fibrosis were observed in the surface of epithelium of the mucosa and connective tissues. Conclusion: The important  point in use of oral medications, in addition to changes in the surface epithelium of the mucosa, is deeper changes that can lead to important and sometimes problematic consequences.
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spelling doaj.art-2b429af1db6e48bc963eb6182f649d312022-12-21T18:44:31ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332016-05-01242164173Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal StudyMH Akhavan Karbassi0SH Tabatabai1KH Kheirollahi2H Kheirollahi3 School of Dentistry School of Dentistry School of Dentistry School of Dentistry Introductions: Recurrent aphthous stomatitis (RAS) is a common disease and suitable treatment has been unsuccessful. The purpose of this study was evaluating oral wound healing process following use of Oralmedic. Methods: In this animal study, mucosal ulcers with the same size were made in the lower lip of 12 mice with the same weight, gender and race. The mice were selected randomly divided into two groups of six mice each, oralmedic and distilled groups. The Oralmedic has been used on the wound in the first group and distilled water was applied on the wound in the second group twice a day for 5 days. On the fifteenth day, biopsy was obtained from wound healing areas and they were investigated through microscopic examination. Results: The epithelium in the restored areas in both two groups was almost normal (p>0.05). In the studied groups, oral medic created different inflammatory effects in the connective tissues. In terms of medicine, formation of the granulation tissue showed a significant difference between two groups, but this difference was not statistically significant. The amount of collagen in the connective tissues were different. Histologic observations showed that after using Oralmedic, some changes such as inflammation, scar formation, and fibrosis were observed in the surface of epithelium of the mucosa and connective tissues. Conclusion: The important  point in use of oral medications, in addition to changes in the surface epithelium of the mucosa, is deeper changes that can lead to important and sometimes problematic consequences.http://jssu.ssu.ac.ir/browse.php?a_code=A-10-2438-1&slc_lang=en&sid=1Aphthous Ulcer Oralmedic Wound Healing
spellingShingle MH Akhavan Karbassi
SH Tabatabai
KH Kheirollahi
H Kheirollahi
Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Aphthous Ulcer
Oralmedic
Wound Healing
title Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
title_full Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
title_fullStr Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
title_full_unstemmed Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
title_short Histopathological Examination of Oralmedic Effects on Oral Wound Healing Process: an Animal Study
title_sort histopathological examination of oralmedic effects on oral wound healing process an animal study
topic Aphthous Ulcer
Oralmedic
Wound Healing
url http://jssu.ssu.ac.ir/browse.php?a_code=A-10-2438-1&slc_lang=en&sid=1
work_keys_str_mv AT mhakhavankarbassi histopathologicalexaminationoforalmediceffectsonoralwoundhealingprocessananimalstudy
AT shtabatabai histopathologicalexaminationoforalmediceffectsonoralwoundhealingprocessananimalstudy
AT khkheirollahi histopathologicalexaminationoforalmediceffectsonoralwoundhealingprocessananimalstudy
AT hkheirollahi histopathologicalexaminationoforalmediceffectsonoralwoundhealingprocessananimalstudy