Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years
Abstract Introduction On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2016.08.003 |
| _version_ | 1819017891385704448 |
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| author | Eero Vuoksimaa Juha O. Rinne Noora Lindgren Kauko Heikkilä Markku Koskenvuo Jaakko Kaprio |
| author_facet | Eero Vuoksimaa Juha O. Rinne Noora Lindgren Kauko Heikkilä Markku Koskenvuo Jaakko Kaprio |
| author_sort | Eero Vuoksimaa |
| collection | DOAJ |
| description | Abstract Introduction On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments. Results The prevalence of dementia was 10% after a mean follow‐up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow‐up of 39 years in the replication sample. Discussion Self‐report risk score predicted cognitive functioning and dementia risk 20–40 years later. |
| first_indexed | 2024-12-21T03:10:44Z |
| format | Article |
| id | doaj.art-2b444810182743c6b5fcf0256614540a |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-21T03:10:44Z |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-2b444810182743c6b5fcf0256614540a2022-12-21T19:17:59ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292016-01-014111812510.1016/j.dadm.2016.08.003Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 yearsEero Vuoksimaa0Juha O. Rinne1Noora Lindgren2Kauko Heikkilä3Markku Koskenvuo4Jaakko Kaprio5Institute for Molecular Medicine Finland, University of HelsinkiHelsinkiFinlandTurku PET CentreUniversity of Turku, Turku University HospitalTurkuFinlandTurku PET CentreUniversity of Turku, Turku University HospitalTurkuFinlandInstitute for Molecular Medicine Finland, University of HelsinkiHelsinkiFinlandClinicum, Department of Public HealthUniversity of HelsinkiHelsinkiFinlandInstitute for Molecular Medicine Finland, University of HelsinkiHelsinkiFinlandAbstract Introduction On the basis of the proxy measures of cognitive reserve, we created a middle age self‐report risk score for early prediction of dementia. Methods We used a longitudinal population‐based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments. Results The prevalence of dementia was 10% after a mean follow‐up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow‐up of 39 years in the replication sample. Discussion Self‐report risk score predicted cognitive functioning and dementia risk 20–40 years later.https://doi.org/10.1016/j.dadm.2016.08.003EducationEarly identificationCognitive reserveDementiaMiddle ageOccupation |
| spellingShingle | Eero Vuoksimaa Juha O. Rinne Noora Lindgren Kauko Heikkilä Markku Koskenvuo Jaakko Kaprio Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Education Early identification Cognitive reserve Dementia Middle age Occupation |
| title | Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years |
| title_full | Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years |
| title_fullStr | Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years |
| title_full_unstemmed | Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years |
| title_short | Middle age self‐report risk score predicts cognitive functioning and dementia in 20–40 years |
| title_sort | middle age self report risk score predicts cognitive functioning and dementia in 20 40 years |
| topic | Education Early identification Cognitive reserve Dementia Middle age Occupation |
| url | https://doi.org/10.1016/j.dadm.2016.08.003 |
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