Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice
Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria. The role of uric acid in the pathogenesis of pre-eclampsia remains largely unclear. The aim of this study was to investigate the effect of elevated uric a...
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/22/3703 |
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| author | Benjamin P. Lüscher Andreina Schoeberlein Daniel V. Surbek Marc U. Baumann |
| author_facet | Benjamin P. Lüscher Andreina Schoeberlein Daniel V. Surbek Marc U. Baumann |
| author_sort | Benjamin P. Lüscher |
| collection | DOAJ |
| description | Hyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria. The role of uric acid in the pathogenesis of pre-eclampsia remains largely unclear. The aim of this study was to investigate the effect of elevated uric acid serum levels during pregnancy on maternal blood pressure and neonatal outcome using two different murine knockout models. Non-pregnant liver-specific GLUT9 knockout (LG9KO) mice showed elevated uric acid serum concentrations but no hypertensive blood pressure levels. During pregnancy, however, blood pressure levels of these animals increased in the second and third trimester, and circadian blood pressure dipping was severely altered when compared to non-pregnant LG9KO mice. The impact of hyperuricemia on fetal development was investigated using a systemic GLUT9 knockout (G9KO) mouse model. Fetal hyperuricemia caused distinctive renal tissue injuries and, subsequently an impaired neonatal growth pattern. These findings provide strong evidence that hyperuricemia plays a major role in the pathogenesis of hypertensive pregnancy disorders such as pre-eclampsia. These novel insights may enable the development of preventive and therapeutic strategies for hyperuricemia-related diseases. |
| first_indexed | 2024-03-09T18:24:14Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:24:14Z |
| publishDate | 2022-11-01 |
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| spelling | doaj.art-2b47d8159ac4404dacc1145bb364e0712023-11-24T07:59:40ZengMDPI AGCells2073-44092022-11-011122370310.3390/cells11223703Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in MiceBenjamin P. Lüscher0Andreina Schoeberlein1Daniel V. Surbek2Marc U. Baumann3Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital, 3010 Bern, SwitzerlandDepartment of Obstetrics and Gynecology, Inselspital, Bern University Hospital, 3010 Bern, SwitzerlandDepartment of Obstetrics and Gynecology, Inselspital, Bern University Hospital, 3010 Bern, SwitzerlandDepartment of Obstetrics and Gynecology, Inselspital, Bern University Hospital, 3010 Bern, SwitzerlandHyperuricemia is a common feature in pregnancies compromised by pre-eclampsia, a pregnancy disease characterized by hypertension and proteinuria. The role of uric acid in the pathogenesis of pre-eclampsia remains largely unclear. The aim of this study was to investigate the effect of elevated uric acid serum levels during pregnancy on maternal blood pressure and neonatal outcome using two different murine knockout models. Non-pregnant liver-specific GLUT9 knockout (LG9KO) mice showed elevated uric acid serum concentrations but no hypertensive blood pressure levels. During pregnancy, however, blood pressure levels of these animals increased in the second and third trimester, and circadian blood pressure dipping was severely altered when compared to non-pregnant LG9KO mice. The impact of hyperuricemia on fetal development was investigated using a systemic GLUT9 knockout (G9KO) mouse model. Fetal hyperuricemia caused distinctive renal tissue injuries and, subsequently an impaired neonatal growth pattern. These findings provide strong evidence that hyperuricemia plays a major role in the pathogenesis of hypertensive pregnancy disorders such as pre-eclampsia. These novel insights may enable the development of preventive and therapeutic strategies for hyperuricemia-related diseases.https://www.mdpi.com/2073-4409/11/22/3703hyperuricemiauric acidpreeclampsiaglucose transporter 9knockout model |
| spellingShingle | Benjamin P. Lüscher Andreina Schoeberlein Daniel V. Surbek Marc U. Baumann Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice Cells hyperuricemia uric acid preeclampsia glucose transporter 9 knockout model |
| title | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice |
| title_full | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice |
| title_fullStr | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice |
| title_full_unstemmed | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice |
| title_short | Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice |
| title_sort | hyperuricemia during pregnancy leads to a preeclampsia like phenotype in mice |
| topic | hyperuricemia uric acid preeclampsia glucose transporter 9 knockout model |
| url | https://www.mdpi.com/2073-4409/11/22/3703 |
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