Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex
The lateral entorhinal cortex (LEC) is thought to bind sensory events with the environment where they took place. To compare the relative influence of transient events and temporally stable environmental stimuli on the firing of LEC cells, we recorded neuron spiking patterns in the region during blo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/28611 |
| _version_ | 1811199309457129472 |
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| author | Maryna Pilkiw Nathan Insel Younghua Cui Caitlin Finney Mark D Morrissey Kaori Takehara-Nishiuchi |
| author_facet | Maryna Pilkiw Nathan Insel Younghua Cui Caitlin Finney Mark D Morrissey Kaori Takehara-Nishiuchi |
| author_sort | Maryna Pilkiw |
| collection | DOAJ |
| description | The lateral entorhinal cortex (LEC) is thought to bind sensory events with the environment where they took place. To compare the relative influence of transient events and temporally stable environmental stimuli on the firing of LEC cells, we recorded neuron spiking patterns in the region during blocks of a trace eyeblink conditioning paradigm performed in two environments and with different conditioning stimuli. Firing rates of some neurons were phasically selective for conditioned stimuli in a way that depended on which room the rat was in; nearly all neurons were tonically selective for environments in a way that depended on which stimuli had been presented in those environments. As rats moved from one environment to another, tonic neuron ensemble activity exhibited prospective information about the conditioned stimulus associated with the environment. Thus, the LEC formed phasic and tonic codes for event-environment associations, thereby accurately differentiating multiple experiences with overlapping features. |
| first_indexed | 2024-04-12T01:45:47Z |
| format | Article |
| id | doaj.art-2b49255649554ce4998928d7727dab32 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:45:47Z |
| publishDate | 2017-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-2b49255649554ce4998928d7727dab322022-12-22T03:53:05ZengeLife Sciences Publications LtdeLife2050-084X2017-07-01610.7554/eLife.28611Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortexMaryna Pilkiw0https://orcid.org/0000-0003-1200-1708Nathan Insel1Younghua Cui2Caitlin Finney3Mark D Morrissey4Kaori Takehara-Nishiuchi5https://orcid.org/0000-0002-7282-7838Department of Cell and Systems Biology, University of Toronto, Toronto, CanadaDepartment of Psychology, University of Toronto, Toronto, Canada; Department of Psychology, University of Montana, Missoula, United StatesDepartment of Psychology, University of Toronto, Toronto, CanadaDepartment of Psychology, University of Toronto, Toronto, CanadaDepartment of Psychology, University of Toronto, Toronto, Canada; Neuroscience Program, University of Toronto, Toronto, CanadaDepartment of Cell and Systems Biology, University of Toronto, Toronto, Canada; Department of Psychology, University of Toronto, Toronto, Canada; Neuroscience Program, University of Toronto, Toronto, CanadaThe lateral entorhinal cortex (LEC) is thought to bind sensory events with the environment where they took place. To compare the relative influence of transient events and temporally stable environmental stimuli on the firing of LEC cells, we recorded neuron spiking patterns in the region during blocks of a trace eyeblink conditioning paradigm performed in two environments and with different conditioning stimuli. Firing rates of some neurons were phasically selective for conditioned stimuli in a way that depended on which room the rat was in; nearly all neurons were tonically selective for environments in a way that depended on which stimuli had been presented in those environments. As rats moved from one environment to another, tonic neuron ensemble activity exhibited prospective information about the conditioned stimulus associated with the environment. Thus, the LEC formed phasic and tonic codes for event-environment associations, thereby accurately differentiating multiple experiences with overlapping features.https://elifesciences.org/articles/28611episodic memorycontextassociative memoryhippocampussingle-unit activityensemble decoding |
| spellingShingle | Maryna Pilkiw Nathan Insel Younghua Cui Caitlin Finney Mark D Morrissey Kaori Takehara-Nishiuchi Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex eLife episodic memory context associative memory hippocampus single-unit activity ensemble decoding |
| title | Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex |
| title_full | Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex |
| title_fullStr | Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex |
| title_full_unstemmed | Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex |
| title_short | Phasic and tonic neuron ensemble codes for stimulus-environment conjunctions in the lateral entorhinal cortex |
| title_sort | phasic and tonic neuron ensemble codes for stimulus environment conjunctions in the lateral entorhinal cortex |
| topic | episodic memory context associative memory hippocampus single-unit activity ensemble decoding |
| url | https://elifesciences.org/articles/28611 |
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