Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study
Background: Maximum decrease of blood pressure and number of minutes of hypotension were independently associated with umbilical arterial pH. However, the impact of hypotension considering the duration of it on umbilical arterial pH is unknown. Methods: Pregnant women aged ≥ 20 years who delivered a...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Brazilian Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001421001871 |
| _version_ | 1818018248890777600 |
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| author | Miwa Kitaguchi Mitsuru Ida Yusuke Naito Yuka Akasaki Masahiko Kawaguchi |
| author_facet | Miwa Kitaguchi Mitsuru Ida Yusuke Naito Yuka Akasaki Masahiko Kawaguchi |
| author_sort | Miwa Kitaguchi |
| collection | DOAJ |
| description | Background: Maximum decrease of blood pressure and number of minutes of hypotension were independently associated with umbilical arterial pH. However, the impact of hypotension considering the duration of it on umbilical arterial pH is unknown. Methods: Pregnant women aged ≥ 20 years who delivered a baby at full-term via a cesarean delivery under a single-shot spinal anesthesia between January 2017 and March 2019 were included. The main outcome was to predict umbilical arterial pH, based on the value of the time integral of hypotension. Patient demographics, patient comorbidities, and intraoperative data, including the total dose of ephedrine and phenylephrine by fetal delivery and cumulative duration of maternal hypotension, were evaluated. Maternal hypotension was reflected as a decrease in systolic arterial pressure and mean arterial pressure to < 80% of baseline values. The systolic arterial pressure and mean arterial pressure were independently included in a multiple regression analysis along with all other explanatory factors to predict the umbilical arterial pH. Results: Of the 416 eligible patients, 381 were enrolled. When including the systolic arterial pressure or mean arterial pressure in the model, emergency cases, the total dose of ephedrine, hypertensive disorders of pregnancy, and systolic arterial pressure or mean arterial pressure values were found to be significant predictive factors of umbilical arterial pH. Conclusion: Our results suggest that an elevated time integral of maternal hypotension may have a negative impact on umbilical arterial pH. Therefore, to minimize the risk of fetal acidosis, maternal hypotension should be prevented with the consideration of vasopressors selection. |
| first_indexed | 2024-04-14T07:37:23Z |
| format | Article |
| id | doaj.art-2b49285bdb7641dc9ff59c5fb0452495 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-04-14T07:37:23Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-2b49285bdb7641dc9ff59c5fb04524952022-12-22T02:05:38ZengElsevierBrazilian Journal of Anesthesiology0104-00142022-07-01724466471Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort studyMiwa Kitaguchi0Mitsuru Ida1Yusuke Naito2Yuka Akasaki3Masahiko Kawaguchi4Nara Medical University, Department of Anesthesiology, Kashihara, JapanCorresponding author.; Nara Medical University, Department of Anesthesiology, Kashihara, JapanNara Medical University, Department of Anesthesiology, Kashihara, JapanNara Medical University, Department of Anesthesiology, Kashihara, JapanNara Medical University, Department of Anesthesiology, Kashihara, JapanBackground: Maximum decrease of blood pressure and number of minutes of hypotension were independently associated with umbilical arterial pH. However, the impact of hypotension considering the duration of it on umbilical arterial pH is unknown. Methods: Pregnant women aged ≥ 20 years who delivered a baby at full-term via a cesarean delivery under a single-shot spinal anesthesia between January 2017 and March 2019 were included. The main outcome was to predict umbilical arterial pH, based on the value of the time integral of hypotension. Patient demographics, patient comorbidities, and intraoperative data, including the total dose of ephedrine and phenylephrine by fetal delivery and cumulative duration of maternal hypotension, were evaluated. Maternal hypotension was reflected as a decrease in systolic arterial pressure and mean arterial pressure to < 80% of baseline values. The systolic arterial pressure and mean arterial pressure were independently included in a multiple regression analysis along with all other explanatory factors to predict the umbilical arterial pH. Results: Of the 416 eligible patients, 381 were enrolled. When including the systolic arterial pressure or mean arterial pressure in the model, emergency cases, the total dose of ephedrine, hypertensive disorders of pregnancy, and systolic arterial pressure or mean arterial pressure values were found to be significant predictive factors of umbilical arterial pH. Conclusion: Our results suggest that an elevated time integral of maternal hypotension may have a negative impact on umbilical arterial pH. Therefore, to minimize the risk of fetal acidosis, maternal hypotension should be prevented with the consideration of vasopressors selection.http://www.sciencedirect.com/science/article/pii/S0104001421001871Anesthesia, spinalArterial pressure, meanCesarean sectionEphedrineFetal bloodHydrogen-ion concentration |
| spellingShingle | Miwa Kitaguchi Mitsuru Ida Yusuke Naito Yuka Akasaki Masahiko Kawaguchi Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study Brazilian Journal of Anesthesiology Anesthesia, spinal Arterial pressure, mean Cesarean section Ephedrine Fetal blood Hydrogen-ion concentration |
| title | Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study |
| title_full | Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study |
| title_fullStr | Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study |
| title_full_unstemmed | Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study |
| title_short | Associated factors with umbilical arterial pH after cesarean delivery under spinal anesthesia: a retrospective cohort study |
| title_sort | associated factors with umbilical arterial ph after cesarean delivery under spinal anesthesia a retrospective cohort study |
| topic | Anesthesia, spinal Arterial pressure, mean Cesarean section Ephedrine Fetal blood Hydrogen-ion concentration |
| url | http://www.sciencedirect.com/science/article/pii/S0104001421001871 |
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