Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans.
Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4595442?pdf=render |
| _version_ | 1828531491169107968 |
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| author | Barbora de Courten Timea Kurdiova Maximilian P J de Courten Vitazoslav Belan Inge Everaert Marek Vician Helena Teede Daniela Gasperikova Giancarlo Aldini Wim Derave Jozef Ukropec Barbara Ukropcova |
| author_facet | Barbora de Courten Timea Kurdiova Maximilian P J de Courten Vitazoslav Belan Inge Everaert Marek Vician Helena Teede Daniela Gasperikova Giancarlo Aldini Wim Derave Jozef Ukropec Barbara Ukropcova |
| author_sort | Barbora de Courten |
| collection | DOAJ |
| description | Carnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists.Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), % body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45±7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to % body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p<0.001) and HDL-cholesterol levels (r = -0.34, p = 0.048). Insulin sensitivity and physical activity were the best predictors of muscle carnosine content after adjustment for adiposity.Our data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose. Moreover, it is negatively associated with HDL-cholesterol and basal energy expenditure. Intervention studies targeting insulin resistance, metabolic and cardiovascular disease risk factors are necessary to evaluate its putative role in the prevention and management of type 2 diabetes and cardiovascular disease. |
| first_indexed | 2024-12-11T22:38:29Z |
| format | Article |
| id | doaj.art-2b495e9e3385441ca6a86e2c953f8159 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:38:29Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2b495e9e3385441ca6a86e2c953f81592022-12-22T00:47:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e013870710.1371/journal.pone.0138707Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans.Barbora de CourtenTimea KurdiovaMaximilian P J de CourtenVitazoslav BelanInge EveraertMarek VicianHelena TeedeDaniela GasperikovaGiancarlo AldiniWim DeraveJozef UkropecBarbara UkropcovaCarnosine is a naturally present dipeptide abundant in skeletal muscle and an over-the counter food additive. Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists.Samples of vastus lateralis muscle were obtained by needle biopsy. We measured muscle carnosine levels (high-performance liquid chromatography), % body fat (bioimpedance), abdominal subcutaneous and visceral adiposity (magnetic resonance imaging), insulin sensitivity (euglycaemic hyperinsulinemic clamp), resting energy expenditure (REE, indirect calorimetry), free-living ambulatory physical activity (accelerometers) and lipid profile in 36 sedentary non-vegetarian middle aged men (45±7 years) with varying degrees of adiposity and glucose tolerance. Muscle carnosine content was positively related to % body fat (r = 0.35, p = 0.04) and subcutaneous (r = 0.38, p = 0.02) but not visceral fat (r = 0.17, p = 0.33). Muscle carnosine content was inversely associated with insulin sensitivity (r = -0.44, p = 0.008), REE (r = -0.58, p<0.001) and HDL-cholesterol levels (r = -0.34, p = 0.048). Insulin sensitivity and physical activity were the best predictors of muscle carnosine content after adjustment for adiposity.Our data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose. Moreover, it is negatively associated with HDL-cholesterol and basal energy expenditure. Intervention studies targeting insulin resistance, metabolic and cardiovascular disease risk factors are necessary to evaluate its putative role in the prevention and management of type 2 diabetes and cardiovascular disease.http://europepmc.org/articles/PMC4595442?pdf=render |
| spellingShingle | Barbora de Courten Timea Kurdiova Maximilian P J de Courten Vitazoslav Belan Inge Everaert Marek Vician Helena Teede Daniela Gasperikova Giancarlo Aldini Wim Derave Jozef Ukropec Barbara Ukropcova Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. PLoS ONE |
| title | Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. |
| title_full | Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. |
| title_fullStr | Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. |
| title_full_unstemmed | Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. |
| title_short | Muscle Carnosine Is Associated with Cardiometabolic Risk Factors in Humans. |
| title_sort | muscle carnosine is associated with cardiometabolic risk factors in humans |
| url | http://europepmc.org/articles/PMC4595442?pdf=render |
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