Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.

Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Many recent studies focused on the interaction between α-synuclein (α-syn) and dopamine in the pathogenesis of PD, and fluorescent anisotropy sug...

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Main Authors: Kazuhiro Nakaso, Naoko Tajima, Satoru Ito, Mari Teraoka, Atsushi Yamashita, Yosuke Horikoshi, Daisuke Kikuchi, Shinsuke Mochida, Kenji Nakashima, Tatsuya Matsura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3573015?pdf=render

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