Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis
BACKGROUND Inflammatory bowel disease (IBD), Crohn’s disease (CD), and Ulcerative colitis (UC) are autoimmune inflammatory diseases of the alimentary tract, which seems to be caused by the interaction of environmental and genetic factors as well as diet and nutritional factors such as vitamin D. Th...
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| Formato: | Artigo |
| Idioma: | English |
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Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences
2018-04-01
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| Series: | Middle East Journal of Digestive Diseases |
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| Acceso en liña: | http://www.mejdd.org/index.php/mejdd/article/view/1888 |
| _version_ | 1829471774164647936 |
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| author | Amrollah Sharifi Saharnaz Nedjat Homayoon Vahedi Gholamreza Veghari Mohammad Javad Hosseinzadeh-Attar |
| author_facet | Amrollah Sharifi Saharnaz Nedjat Homayoon Vahedi Gholamreza Veghari Mohammad Javad Hosseinzadeh-Attar |
| author_sort | Amrollah Sharifi |
| collection | DOAJ |
| description | BACKGROUND
Inflammatory bowel disease (IBD), Crohn’s disease (CD), and Ulcerative colitis (UC) are autoimmune inflammatory diseases of the alimentary tract, which seems to be caused by the interaction of environmental and genetic factors as well as diet and nutritional factors such as vitamin D. The aim of this study was to assess the vitamin D status and its associations with erythrocyte sedimentation rate (ESR), and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers in patients with UC.
METHODS
In this analytical cross-sectional study 90 patients with mild to moderate UC who were resident of Tehran were assessed. 25(OH)D, parathyroid hormone (PTH), ESR and hs-CRP were measured. Dietary intake was assessed by 3-day 24h diet recall. Statistical analyses were performed using STATA (Version 12).
RESULTS
The average serum 25-OH-vitamin D3 was 33.1 ± 8.3 ng/mL and 38.9% of the patients were vitamin D deficient or insufficient (37.3% of men and 41% of women). No significant correlation between serum 25(OH)D and hs-CRP, ESR, body mass index (BMI), and disease duration was found. There were no significant differences in serum 25(OH)D between men and women. Mean daily dietary vitamin D and calcium intakes were 189.5 Iu (95% CI: 176.0 - 203.1) and 569.5 mg (95% CI: 538.8 - 600.2) respectively.
CONCLUSION
In this cross-sectional study 38.9% of the patients with mild to moderate UC were vitamin D deficient or insufficient and vitamin D level was not correlated to ESR and/or hs-CRP. More studies are needed to investigate the effect of vitamin D in the pathogenesis of UC or as a part of its treatment. |
| first_indexed | 2024-12-14T02:02:26Z |
| format | Article |
| id | doaj.art-2b4a1eeb51fa4577b6877d6889acb2a6 |
| institution | Directory Open Access Journal |
| issn | 2008-5230 2008-5249 |
| language | English |
| last_indexed | 2024-12-14T02:02:26Z |
| publishDate | 2018-04-01 |
| publisher | Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Digestive Diseases |
| spelling | doaj.art-2b4a1eeb51fa4577b6877d6889acb2a62022-12-21T23:20:58ZengIranian Association of Gastroenterology and Hepatology, Shiraz University of Medical SciencesMiddle East Journal of Digestive Diseases2008-52302008-52492018-04-01102848910.15171/mejdd.2018.95Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative ColitisAmrollah Sharifi0Saharnaz Nedjat1Homayoon Vahedi2Gholamreza Veghari3Mohammad Javad Hosseinzadeh-Attar4Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GOUMS), Gorgan, IranEpidemiology and Biostatistics Department, School of Public Health, Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, IranDigestive Disease Research Center, Digestive Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranBiochemistry and Metabolic Disorders Research Center, Golestan University of Medical Sciences. Gorgan, IranDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranBACKGROUND Inflammatory bowel disease (IBD), Crohn’s disease (CD), and Ulcerative colitis (UC) are autoimmune inflammatory diseases of the alimentary tract, which seems to be caused by the interaction of environmental and genetic factors as well as diet and nutritional factors such as vitamin D. The aim of this study was to assess the vitamin D status and its associations with erythrocyte sedimentation rate (ESR), and high-sensitivity C-reactive protein (hs-CRP) as inflammatory markers in patients with UC. METHODS In this analytical cross-sectional study 90 patients with mild to moderate UC who were resident of Tehran were assessed. 25(OH)D, parathyroid hormone (PTH), ESR and hs-CRP were measured. Dietary intake was assessed by 3-day 24h diet recall. Statistical analyses were performed using STATA (Version 12). RESULTS The average serum 25-OH-vitamin D3 was 33.1 ± 8.3 ng/mL and 38.9% of the patients were vitamin D deficient or insufficient (37.3% of men and 41% of women). No significant correlation between serum 25(OH)D and hs-CRP, ESR, body mass index (BMI), and disease duration was found. There were no significant differences in serum 25(OH)D between men and women. Mean daily dietary vitamin D and calcium intakes were 189.5 Iu (95% CI: 176.0 - 203.1) and 569.5 mg (95% CI: 538.8 - 600.2) respectively. CONCLUSION In this cross-sectional study 38.9% of the patients with mild to moderate UC were vitamin D deficient or insufficient and vitamin D level was not correlated to ESR and/or hs-CRP. More studies are needed to investigate the effect of vitamin D in the pathogenesis of UC or as a part of its treatment.http://www.mejdd.org/index.php/mejdd/article/view/1888Vitamin DUlcerative ColitisInflammationInflammatory Bowel Disease |
| spellingShingle | Amrollah Sharifi Saharnaz Nedjat Homayoon Vahedi Gholamreza Veghari Mohammad Javad Hosseinzadeh-Attar Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis Middle East Journal of Digestive Diseases Vitamin D Ulcerative Colitis Inflammation Inflammatory Bowel Disease |
| title | Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis |
| title_full | Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis |
| title_fullStr | Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis |
| title_full_unstemmed | Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis |
| title_short | Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis |
| title_sort | vitamin d status and its relation to inflammatory markers in patients with mild to moderate ulcerative colitis |
| topic | Vitamin D Ulcerative Colitis Inflammation Inflammatory Bowel Disease |
| url | http://www.mejdd.org/index.php/mejdd/article/view/1888 |
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