Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches
Regardless of the size of a patient’s Patent Ductus Arteriosus (PDA), it is crucial for paediatric and adult cardiologists to have a thorough understanding of the condition’s origin, clinical ramifications, and treatment options. Possessing a PDA, no matter how little, might cause complications. Ibu...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2023-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/17845/63242_CE[Ra1]_F[SK]_PF1(HB_SHU)_PFA(HB_KM)_PN(KM).pdf |
| _version_ | 1797830391332077568 |
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| author | Kushal Desai Amar Taksande |
| author_facet | Kushal Desai Amar Taksande |
| author_sort | Kushal Desai |
| collection | DOAJ |
| description | Regardless of the size of a patient’s Patent Ductus Arteriosus (PDA), it is crucial for paediatric and adult cardiologists to have a thorough understanding of the condition’s origin, clinical ramifications, and treatment options. Possessing a PDA, no matter how little, might cause complications. Ibuprofen and indomethacin, both cyclo-oxygenase (COX) inhibitors, are used as the gold standard pharmacologic therapy for closing a PDA that has been produced surgically. These non selective COX inhibitors bring about ductal constriction, in addition to lowering the synthesis of prostaglandin. However, these drugs may also have a broad array of unintended consequences. Interest in paracetamol for PDA constriction has recently increased due to fewer adverse effects than indomethacin or ibuprofen. Evidence that paracetamol is now a topic of intense study lends credence to this hypothesis. Information on the long term effects of paracetamol is scarce in paediatric population. |
| first_indexed | 2024-04-09T13:34:48Z |
| format | Article |
| id | doaj.art-2b4b4b26672847a4b59933dddecb276b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-09T13:34:48Z |
| publishDate | 2023-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-2b4b4b26672847a4b59933dddecb276b2023-05-09T10:37:56ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-05-01175SE01SE0410.7860/JCDR/2023/63242.17845Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug ApproachesKushal Desai0Amar Taksande1Postgraduate Resident, Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.Professor and Head, Department of Paediatrics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.Regardless of the size of a patient’s Patent Ductus Arteriosus (PDA), it is crucial for paediatric and adult cardiologists to have a thorough understanding of the condition’s origin, clinical ramifications, and treatment options. Possessing a PDA, no matter how little, might cause complications. Ibuprofen and indomethacin, both cyclo-oxygenase (COX) inhibitors, are used as the gold standard pharmacologic therapy for closing a PDA that has been produced surgically. These non selective COX inhibitors bring about ductal constriction, in addition to lowering the synthesis of prostaglandin. However, these drugs may also have a broad array of unintended consequences. Interest in paracetamol for PDA constriction has recently increased due to fewer adverse effects than indomethacin or ibuprofen. Evidence that paracetamol is now a topic of intense study lends credence to this hypothesis. Information on the long term effects of paracetamol is scarce in paediatric population.https://www.jcdr.net/articles/PDF/17845/63242_CE[Ra1]_F[SK]_PF1(HB_SHU)_PFA(HB_KM)_PN(KM).pdfacetaminophenibuprofenindomethacinparacetamol |
| spellingShingle | Kushal Desai Amar Taksande Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches Journal of Clinical and Diagnostic Research acetaminophen ibuprofen indomethacin paracetamol |
| title | Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches |
| title_full | Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches |
| title_fullStr | Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches |
| title_full_unstemmed | Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches |
| title_short | Different Medicinal Treatment Modalities in the Management of Patent Ductus Arteriosus in Paediatric Population- A Narrative Review of Available Drug Approaches |
| title_sort | different medicinal treatment modalities in the management of patent ductus arteriosus in paediatric population a narrative review of available drug approaches |
| topic | acetaminophen ibuprofen indomethacin paracetamol |
| url | https://www.jcdr.net/articles/PDF/17845/63242_CE[Ra1]_F[SK]_PF1(HB_SHU)_PFA(HB_KM)_PN(KM).pdf |
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