Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
Abstract Background To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. Methods A sample of 152 IMRT-treated,...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-11-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3780-9 |
| _version_ | 1819056894339186688 |
|---|---|
| author | Lu-Lu Zhang Guan-Qun Zhou Zhen-Yu Qi Xiao-Jun He Jia-Xiang Li Ling-Long Tang Yan-Ping Mao Ai-Hua Lin Jun Ma Ying Sun |
| author_facet | Lu-Lu Zhang Guan-Qun Zhou Zhen-Yu Qi Xiao-Jun He Jia-Xiang Li Ling-Long Tang Yan-Ping Mao Ai-Hua Lin Jun Ma Ying Sun |
| author_sort | Lu-Lu Zhang |
| collection | DOAJ |
| description | Abstract Background To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. Methods A sample of 152 IMRT-treated, biopsy-proven, nondisseminated NPC patients were retrospectively analysed. All had documented IMRT treatment plans and had returned for follow-up review at 4 years post-radiotherapy. Spasm of the sternocleidomastoid (SCM) muscle was graded from 0 to 3 (absent to severe) and this grade served as the clinical endpoint. Risk factors were identified using logistic regression analysis. Results Within 4 years of radiotherapy, neck muscle spasm developed in 23.68% of the patients; Grades 0, 1, 2 and 3 were respectively assigned to 83.55, 7.57, 6.58 and 2.30% of assessed SCMs. Multivariate analysis indicated that gender, N stage, V60 (percentage of SCM volume that received >60 Gy) were independent prognostic variables, and that the optimal threshold for using V60 to predict neck muscle spasm was 61.92% (sensitivity = 0.900, specificity = 0.953). Conclusions Gender, N stage and V60 were independent predictive factors for post-radiotherapy neck muscle spasm, and a V60 of ≤61.92% in the SCM was relatively safe. |
| first_indexed | 2024-12-21T13:30:40Z |
| format | Article |
| id | doaj.art-2b503c4ecb774fe5927b05470892dd7b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-21T13:30:40Z |
| publishDate | 2017-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-2b503c4ecb774fe5927b05470892dd7b2022-12-21T19:02:19ZengBMCBMC Cancer1471-24072017-11-011711910.1186/s12885-017-3780-9Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapyLu-Lu Zhang0Guan-Qun Zhou1Zhen-Yu Qi2Xiao-Jun He3Jia-Xiang Li4Ling-Long Tang5Yan-Ping Mao6Ai-Hua Lin7Jun Ma8Ying Sun9Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Clinical Medicine, School of Public Health, Sun Yat-sen UniversityDepartment of Oncology, First People’s Hospital of Zhaoqing CityDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Oncology, First People’s Hospital of Zhaoqing CityDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineDepartment of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer MedicineAbstract Background To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. Methods A sample of 152 IMRT-treated, biopsy-proven, nondisseminated NPC patients were retrospectively analysed. All had documented IMRT treatment plans and had returned for follow-up review at 4 years post-radiotherapy. Spasm of the sternocleidomastoid (SCM) muscle was graded from 0 to 3 (absent to severe) and this grade served as the clinical endpoint. Risk factors were identified using logistic regression analysis. Results Within 4 years of radiotherapy, neck muscle spasm developed in 23.68% of the patients; Grades 0, 1, 2 and 3 were respectively assigned to 83.55, 7.57, 6.58 and 2.30% of assessed SCMs. Multivariate analysis indicated that gender, N stage, V60 (percentage of SCM volume that received >60 Gy) were independent prognostic variables, and that the optimal threshold for using V60 to predict neck muscle spasm was 61.92% (sensitivity = 0.900, specificity = 0.953). Conclusions Gender, N stage and V60 were independent predictive factors for post-radiotherapy neck muscle spasm, and a V60 of ≤61.92% in the SCM was relatively safe.http://link.springer.com/article/10.1186/s12885-017-3780-9Nasopharyngeal carcinomaNeck muscle spasmIntensity-modulated radiotherapyDose tolerance |
| spellingShingle | Lu-Lu Zhang Guan-Qun Zhou Zhen-Yu Qi Xiao-Jun He Jia-Xiang Li Ling-Long Tang Yan-Ping Mao Ai-Hua Lin Jun Ma Ying Sun Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy BMC Cancer Nasopharyngeal carcinoma Neck muscle spasm Intensity-modulated radiotherapy Dose tolerance |
| title | Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy |
| title_full | Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy |
| title_fullStr | Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy |
| title_full_unstemmed | Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy |
| title_short | Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy |
| title_sort | patient and treatment related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity modulated radiotherapy |
| topic | Nasopharyngeal carcinoma Neck muscle spasm Intensity-modulated radiotherapy Dose tolerance |
| url | http://link.springer.com/article/10.1186/s12885-017-3780-9 |
| work_keys_str_mv | AT luluzhang patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT guanqunzhou patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT zhenyuqi patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT xiaojunhe patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT jiaxiangli patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT linglongtang patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT yanpingmao patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT aihualin patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT junma patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy AT yingsun patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy |