Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish
Introduction. Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis. Methods. Transgenic Tg (flk1: EGFP) zebrafish embryos were used to identify the effects of some cardiov...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/1958046 |
| _version_ | 1797835728450748416 |
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| author | Hui Lv Bo Liu Yongwen Qin |
| author_facet | Hui Lv Bo Liu Yongwen Qin |
| author_sort | Hui Lv |
| collection | DOAJ |
| description | Introduction. Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis. Methods. Transgenic Tg (flk1: EGFP) zebrafish embryos were used to identify the effects of some cardiovascular drugs on angiogenesis during vertebral development in vivo. Zebrafish embryos at a one-cell stage or two-cell stage were cultured with embryo medium containing cardiovascular drugs at a final solvent concentration of 0.5% (V/V) dimethyl sulfoxide (DMSO) for 24 hours in 24-well plates. Results. We found that 6 drugs including isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium may affect angiogenesis by vascular endothelial growth factor (VEGF) signaling pathway. Conclusion. These new findings of some cardiovascular drugs should improve the treatment of cardiovascular diseases. |
| first_indexed | 2024-04-09T14:58:18Z |
| format | Article |
| id | doaj.art-2b5047c2f7c044eea0e3ce83e50240a2 |
| institution | Directory Open Access Journal |
| issn | 1466-1861 |
| language | English |
| last_indexed | 2024-04-09T14:58:18Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj.art-2b5047c2f7c044eea0e3ce83e50240a22023-05-02T00:00:02ZengHindawi LimitedMediators of Inflammation1466-18612023-01-01202310.1155/2023/1958046Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic ZebrafishHui Lv0Bo Liu1Yongwen Qin2Department of Cardiovascular DiseaseDepartment of Cardiovascular DiseaseDepartment of Cardiovascular DiseaseIntroduction. Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis. Methods. Transgenic Tg (flk1: EGFP) zebrafish embryos were used to identify the effects of some cardiovascular drugs on angiogenesis during vertebral development in vivo. Zebrafish embryos at a one-cell stage or two-cell stage were cultured with embryo medium containing cardiovascular drugs at a final solvent concentration of 0.5% (V/V) dimethyl sulfoxide (DMSO) for 24 hours in 24-well plates. Results. We found that 6 drugs including isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium may affect angiogenesis by vascular endothelial growth factor (VEGF) signaling pathway. Conclusion. These new findings of some cardiovascular drugs should improve the treatment of cardiovascular diseases.http://dx.doi.org/10.1155/2023/1958046 |
| spellingShingle | Hui Lv Bo Liu Yongwen Qin Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish Mediators of Inflammation |
| title | Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish |
| title_full | Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish |
| title_fullStr | Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish |
| title_full_unstemmed | Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish |
| title_short | Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish |
| title_sort | investigation of the effects of some cardiovascular drugs on angiogenesis by transgenic zebrafish |
| url | http://dx.doi.org/10.1155/2023/1958046 |
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