Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces
<b>Background:</b> Titanium (Ti) is one of the most popular implant materials, and its surface titanium dioxide (TiO<sub>2</sub>) provides good biocompatibility. The coagulation of blood on Ti implants plays a key role in wound healing and cell growth at the implant site; how...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/17/2623 |
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| author | Her-Hsiung Huang Zhi-Hwa Chen Diem Thuy Nguyen Chuan-Ming Tseng Chiang-Sang Chen Jean-Heng Chang |
| author_facet | Her-Hsiung Huang Zhi-Hwa Chen Diem Thuy Nguyen Chuan-Ming Tseng Chiang-Sang Chen Jean-Heng Chang |
| author_sort | Her-Hsiung Huang |
| collection | DOAJ |
| description | <b>Background:</b> Titanium (Ti) is one of the most popular implant materials, and its surface titanium dioxide (TiO<sub>2</sub>) provides good biocompatibility. The coagulation of blood on Ti implants plays a key role in wound healing and cell growth at the implant site; however, researchers have yet to fully elucidate the mechanism underlying this process on TiO<sub>2</sub>. <b>Methods:</b> This study examined the means by which blood coagulation was affected by the crystal structure of TiO<sub>2</sub> thin films (thickness < 50 nm), including anatase, rutile, and mixed anatase/rutile. The films were characterized in terms of roughness using an atomic force microscope, thickness using an X-ray photoelectron spectrometer, and crystal structure using transmission electron microscopy. The surface energy and dielectric constant of the surface films were measured using a contact angle goniometer and the parallel plate method, respectively. Blood coagulation properties (including clotting time, factor XII contact activation, fibrinogen adsorption, fibrin attachment, and platelet adhesion) were then assessed on the various test specimens. <b>Results:</b> All of the TiO<sub>2</sub> films were similar in terms of surface roughness, thickness, and surface energy (hydrophilicity); however, the presence of rutile structures was associated with a higher dielectric constant, which induced the activation of factor XII, the formation of fibrin network, and platelet adhesion. <b>Conclusions:</b> This study provides detailed information related to the effects of TiO<sub>2</sub> crystal structures on blood coagulation properties on Ti implant surfaces. |
| first_indexed | 2024-03-10T01:57:37Z |
| format | Article |
| id | doaj.art-2b5106f66e1c4c2aa305ae78048a4f54 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:57:37Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2b5106f66e1c4c2aa305ae78048a4f542023-11-23T12:54:05ZengMDPI AGCells2073-44092022-08-011117262310.3390/cells11172623Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant SurfacesHer-Hsiung Huang0Zhi-Hwa Chen1Diem Thuy Nguyen2Chuan-Ming Tseng3Chiang-Sang Chen4Jean-Heng Chang5Department of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, TaiwanInstitute of Oral Biology, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Dentistry, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Materials Engineering and Center for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei City 243, TaiwanDepartment of Orthopedics, Far Eastern Memorial Hospital, New Taipei City 220, TaiwanDental Department, Cheng Hsin General Hospital, Taipei 112, Taiwan<b>Background:</b> Titanium (Ti) is one of the most popular implant materials, and its surface titanium dioxide (TiO<sub>2</sub>) provides good biocompatibility. The coagulation of blood on Ti implants plays a key role in wound healing and cell growth at the implant site; however, researchers have yet to fully elucidate the mechanism underlying this process on TiO<sub>2</sub>. <b>Methods:</b> This study examined the means by which blood coagulation was affected by the crystal structure of TiO<sub>2</sub> thin films (thickness < 50 nm), including anatase, rutile, and mixed anatase/rutile. The films were characterized in terms of roughness using an atomic force microscope, thickness using an X-ray photoelectron spectrometer, and crystal structure using transmission electron microscopy. The surface energy and dielectric constant of the surface films were measured using a contact angle goniometer and the parallel plate method, respectively. Blood coagulation properties (including clotting time, factor XII contact activation, fibrinogen adsorption, fibrin attachment, and platelet adhesion) were then assessed on the various test specimens. <b>Results:</b> All of the TiO<sub>2</sub> films were similar in terms of surface roughness, thickness, and surface energy (hydrophilicity); however, the presence of rutile structures was associated with a higher dielectric constant, which induced the activation of factor XII, the formation of fibrin network, and platelet adhesion. <b>Conclusions:</b> This study provides detailed information related to the effects of TiO<sub>2</sub> crystal structures on blood coagulation properties on Ti implant surfaces.https://www.mdpi.com/2073-4409/11/17/2623titanium implant surfacetitanium dioxidecrystal structuredielectric constantblood coagulation |
| spellingShingle | Her-Hsiung Huang Zhi-Hwa Chen Diem Thuy Nguyen Chuan-Ming Tseng Chiang-Sang Chen Jean-Heng Chang Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces Cells titanium implant surface titanium dioxide crystal structure dielectric constant blood coagulation |
| title | Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces |
| title_full | Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces |
| title_fullStr | Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces |
| title_full_unstemmed | Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces |
| title_short | Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces |
| title_sort | blood coagulation on titanium dioxide films with various crystal structures on titanium implant surfaces |
| topic | titanium implant surface titanium dioxide crystal structure dielectric constant blood coagulation |
| url | https://www.mdpi.com/2073-4409/11/17/2623 |
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