Mitochondria-Shaping Proteins and Chemotherapy
The emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynam...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.769036/full |
| _version_ | 1818402484503183360 |
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| author | Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao |
| author_facet | Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao |
| author_sort | Longlong Xie |
| collection | DOAJ |
| description | The emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynamics are referred to as “shaping proteins”. Marked heterogeneity has been observed in the response of tumor cells to chemotherapy, which is associated with imbalances in mitochondrial dynamics and function leading to adaptive and acquired resistance to chemotherapeutic agents. Therefore, targeting mitochondria-shaping proteins may prove to be a promising approach to treat chemotherapy resistant cancers. In this review, we summarize the alterations of mitochondrial dynamics in chemotherapeutic processing and the antitumor mechanisms by which chemotherapy drugs synergize with mitochondria-shaping proteins. These might shed light on new biomarkers for better prediction of cancer chemosensitivity and contribute to the exploitation of potent therapeutic strategies for the clinical treatment of cancers. |
| first_indexed | 2024-12-14T08:09:06Z |
| format | Article |
| id | doaj.art-2b515027fa3042b2ac3959e84e9240a0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T08:09:06Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2b515027fa3042b2ac3959e84e9240a02022-12-21T23:10:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.769036769036Mitochondria-Shaping Proteins and ChemotherapyLonglong Xie0Longlong Xie1Longlong Xie2Tiansheng Zhou3Yujun Xie4Ann M. Bode5Ya Cao6Ya Cao7Ya Cao8Ya Cao9Ya Cao10Hunan Children’s Hospital, The Pediatric Academy of University of South China, Changsha, ChinaKey Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaCancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, ChinaHunan Children’s Hospital, The Pediatric Academy of University of South China, Changsha, ChinaHunan Children’s Hospital, The Pediatric Academy of University of South China, Changsha, ChinaThe Hormel Institute, University of Minnesota, Austin, MN, United StatesKey Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaCancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, ChinaResearch Center for Technologies of Nucleic Acid-Based Diagnostics and Therapeutics Hunan Province, Changsha, ChinaMolecular Imaging Research Center of Central South University, Changsha, ChinaNational Joint Engineering Research Center for Genetic Diagnostics of Infectious Diseases and Cancer, Changsha, ChinaThe emergence, in recent decades, of an entirely new area of “Mitochondrial dynamics”, which consists principally of fission and fusion, reflects the recognition that mitochondria play a significant role in human tumorigenesis and response to therapeutics. Proteins that determine mitochondrial dynamics are referred to as “shaping proteins”. Marked heterogeneity has been observed in the response of tumor cells to chemotherapy, which is associated with imbalances in mitochondrial dynamics and function leading to adaptive and acquired resistance to chemotherapeutic agents. Therefore, targeting mitochondria-shaping proteins may prove to be a promising approach to treat chemotherapy resistant cancers. In this review, we summarize the alterations of mitochondrial dynamics in chemotherapeutic processing and the antitumor mechanisms by which chemotherapy drugs synergize with mitochondria-shaping proteins. These might shed light on new biomarkers for better prediction of cancer chemosensitivity and contribute to the exploitation of potent therapeutic strategies for the clinical treatment of cancers.https://www.frontiersin.org/articles/10.3389/fonc.2021.769036/fullMitochondria-shaping proteinschemotherapyvirusenergy metabolismtargeted drugs |
| spellingShingle | Longlong Xie Longlong Xie Longlong Xie Tiansheng Zhou Yujun Xie Ann M. Bode Ya Cao Ya Cao Ya Cao Ya Cao Ya Cao Mitochondria-Shaping Proteins and Chemotherapy Frontiers in Oncology Mitochondria-shaping proteins chemotherapy virus energy metabolism targeted drugs |
| title | Mitochondria-Shaping Proteins and Chemotherapy |
| title_full | Mitochondria-Shaping Proteins and Chemotherapy |
| title_fullStr | Mitochondria-Shaping Proteins and Chemotherapy |
| title_full_unstemmed | Mitochondria-Shaping Proteins and Chemotherapy |
| title_short | Mitochondria-Shaping Proteins and Chemotherapy |
| title_sort | mitochondria shaping proteins and chemotherapy |
| topic | Mitochondria-shaping proteins chemotherapy virus energy metabolism targeted drugs |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.769036/full |
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